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Chemical Compound Review:

ALMITRINE 6-[4-[bis(4-fluorophenyl) methyl]piperazin...

Synonyms: Almitrin, Almitrina, Vectarion, Almitrinum, SureCN769301, ...

Giesbrecht, G.G. et al., Lagneaux, D., Palecek, F. et al.

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Disease relevance of ALMITRINE

With ALM, saturation did not differ from PL during air breathing but significantly exceeded SaO2 with PL, by 3.4% during resting hypoxia, by 4.0% at the start of exercise, and by 5.9% at exhaustion [1].

High impact information on ALMITRINE

ALM was associated with an increased heart rate during room air breathing but not during hypoxia [1].
N2 test, NaCN test, 20 s of 5% O2 inhalation and almitrine bismesylate (ALM) were used as PCS, ranged in the order of their relative intensities, from the ventilatory responses observed in IR-rats [2].

Analytical, diagnostic and therapeutic context of ALMITRINE

The respiratory response and changes of functional residual lung capacity were measured in the rat after intravenous administration of the drug S 2620 in a dose of 0.4 mg/kg [3].

References

Exercise endurance and arterial desaturation in normobaric hypoxia with increased chemosensitivity. Giesbrecht, G.G., Puddy, A., Ahmed, M., Younes, M., Anthonisen, N.R. J. Appl. Physiol. (1991) [Pubmed]
Relation between peripheral chemoreceptors stimulation and pulmonary arterial blood pressure in rats. Lagneaux, D. Arch. Int. Physiol. Biochim. (1986) [Pubmed]
Functional residual lung capacity in rats affected by a carotid body stimulant. Palecek, F., Chválová, M. Archives internationales de pharmacodynamie et de thérapie. (1984) [Pubmed]

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