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Chemical Compound Review:

hdsf hexadecane-1-sulfonyl fluoride

Synonyms: CHEMBL94809, AM-374, AG-J-80197, CHEBI:43275, AC1Q4OYJ, ...

Horrevoets, A.J. et al., König, B. et al., Horrevoets, A.J. et al.

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Disease relevance of Hexadecylsulfonyl fluoride

Activation of reconstituted Escherichia coli outer-membrane phospholipase A by membrane-perturbing peptides results in an increased reactivity towards the affinity label hexadecanesulfonyl fluoride [1].

High impact information on Hexadecylsulfonyl fluoride

Lipase activity in the P. aeruginosa culture supernatant was inhibited by treatment with the lipase-specific inhibitor hexadecylsulfonyl fluoride, leaving the activity of PLC unaffected [2].
On the basis of the kinetics of inactivation of OM PLA by hexadecanesulfonyl fluoride, we discuss a possible catalytic mechanism of the enzyme [3].
Analysis of the rates of inactivation of OM PLA by hexadecanesulfonyl fluoride in vesicles composed of various phospholipids indicated that activation of the enzyme by membrane-perturbing peptides can be accurately quantified with this affinity label [1].

Associations of Hexadecylsulfonyl fluoride with other chemical compounds

In detergent and substrate micelles, the rate constant for the sulfonylation of the active-center serine of the purified OM PLA by the affinity label hexadecanesulfonyl fluoride depends on amphiphile concentration [1].

References

Activation of reconstituted Escherichia coli outer-membrane phospholipase A by membrane-perturbing peptides results in an increased reactivity towards the affinity label hexadecanesulfonyl fluoride. Horrevoets, A.J., Francke, C., Verheij, H.M., de Haas, G.H. Eur. J. Biochem. (1991) [Pubmed]
Role of Pseudomonas aeruginosa lipase in inflammatory mediator release from human inflammatory effector cells (platelets, granulocytes, and monocytes. König, B., Jaeger, K.E., Sage, A.E., Vasil, M.L., König, W. Infect. Immun. (1996) [Pubmed]
Inactivation of Escherichia coli outer-membrane phospholipase A by the affinity label hexadecanesulfonyl fluoride. Evidence for an active-site serine. Horrevoets, A.J., Verheij, H.M., de Haas, G.H. Eur. J. Biochem. (1991) [Pubmed]

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