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Chemical Compound Review

Phyllanthin     4-[(2R,3R)-3-[(3,4- dimethoxyphenyl)methyl]...

Synonyms: NSC-619043, NSC619043, AC1L7DK7, NCI60_005684, C10746, ...
 
 
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Disease relevance of C10746

  • Ten lignans (2-11) and a series of azalignans including 1-aryl-pyrronaphthalenes 20-24 and 3-N-alkylaminomethyl-1-arylnaphthalenes 25-28, structurally related to two HIV reverse transcriptase inhibitors, retrojusticidin B and phyllamyricin A, were prepared from phyllanthin (1) for evaluation of anti-HIV activities [1].
 

High impact information on C10746

  • AMARUS derivatives: the hexane extract (HE, 100 mug/mL), the lignans-rich fraction (LRF, 100 mug/mL) and the lignans nirtetralin (NIRT, 43.2 mug/mL), niranthin (NIRA, 43 mug/mL) or phyllanthin (PHYLLA, 43 mug/mL) exerted cytotoxic effects on K-562 cells with 40.3, 66.0, 62.0, 61.0 or 24.1 % of cell death, respectively [2].
  • Given orally, the hexane extract (HE), the lignan-rich fraction (LRF), or the lignans phyltetralin, nirtetralin, niranthin, but not hypophyllanthin or phyllanthin, inhibited carrageenan (Cg)-induced paw oedema and neutrophil influx [3].
  • High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus [4].
 

Associations of C10746 with other chemical compounds

References

  1. Preparation and anti-HIV activities of retrojusticidin B analogs and azalignans. Sagar, K.S., Chang, C.C., Wang, W.K., Lin, J.Y., Lee, S.S. Bioorg. Med. Chem. (2004) [Pubmed]
  2. The Cytotoxic Effect and the Multidrug Resistance Reversing Action of Lignans from Phyllanthus amarus. Leite, D.F., Kassuya, C.A., Mazzuco, T.L., Silvestre, A., de Melo, L.V., Rehder, V.L., Rumjanek, V.M., Calixto, J.B. Planta Med. (2006) [Pubmed]
  3. Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus. Kassuya, C.A., Leite, D.F., de Melo, L.V., Rehder, V.L., Calixto, J.B. Planta Med. (2005) [Pubmed]
  4. High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus. Dhalwal, K., Biradar, Y.S., Rajani, M. Journal of AOAC International. (2006) [Pubmed]
 
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