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Chemical Compound Review:

Bunolol 5-[2-hydroxy-3-(tert- butylamino)propoxy]-3...

Synonyms: Bunololo, Bunololum, l-Bunolol, Bunolol [INN], CHEMBL293030, ...

Li, F. et al., Commarato, M.A. et al., Tocco, D.J. et al., Chen, C.C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LEVOBUNOLOL

The oral beta-adrenoceptor blocking activity of bunolol, propanolol, and their levo-isomers was compared against isoproterenol- and treadmill exercise-induced tachycardias in normal conscious dogs [1].

High impact information on LEVOBUNOLOL

In the heart and lung tissue of rats, racemic timolol, propranolol, bunolol, and bunitrolol were approximately equally effective in competing for the binding sites of 14C-timolol [2].
The half-life of bunolol was approximately 1.26 hours in the aqueous humor and 1.63 hours in the ciliary body [3].

Analytical, diagnostic and therapeutic context of LEVOBUNOLOL

Determination of the enantiomers of bunolol in human urine by high-performance liquid chromatography on a chiral AGP stationary phase and identification of their metabolites by gas chromatography-mass spectrometry [4].

References

Levo-bunolol and propranolol: further evaluation of oral beta-blocking activity in conscious dogs. Commarato, M.A., Giardino, E.C., Kopia, G.A., Kaplan, H.R. Archives internationales de pharmacodynamie et de thérapie. (1977) [Pubmed]
Stereospecific binding of timolol, a beta-adrenergic blocking agent. Tocco, D.J., Hooke, K.F., Deluna, F.A., Duncan, A.E. Drug Metab. Dispos. (1976) [Pubmed]
The disposition of bunolol in the rabbit eye. Chen, C.C., Anderson, J., Shackleton, M., Attard, J. Journal of ocular pharmacology. (1987) [Pubmed]
Determination of the enantiomers of bunolol in human urine by high-performance liquid chromatography on a chiral AGP stationary phase and identification of their metabolites by gas chromatography-mass spectrometry. Li, F., Cooper, S.F., Côté, M., Ayotte, C. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]

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