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Chemical Compound Review:

CCRIS 5585 1,1-diethyl-3-methyl-3- nitroso-urea

Synonyms: AG-F-68891, CTK4J2396, LS-159807, BRN 2249848, AC1L220P, ...

Lijinsky, W. et al., Lijinsky, W. et al., Ketkar, M.B. et al.

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Disease relevance of Nitrosomethyldiaethylharnstoff

Nitrosomethyldiethylurea induced almost exclusively a high incidence of both astrocytomas of the brain and tumors of the spinal cord [1].

High impact information on Nitrosomethyldiaethylharnstoff

Tumors of nervous origin arose after treatment with nitrosotrimethylurea (3/30), notrosotriethylurea (7/30), nitrosomethyldiethylurea (23/30), and nitrosoethyldimethylurea (8/30) [2].

Analytical, diagnostic and therapeutic context of Nitrosomethyldiaethylharnstoff

Laboratory-bred European hamsters received subcutaneous injections of 1,1-diethyl-3-methyl-3-nitrosourea once weekly for life [3].

References

Carcinogenicity of nitrosotrialkylureas in Fischer 344 rats. Lijinsky, W., Reuber, M.D., Blackwell, B.N. J. Natl. Cancer Inst. (1980) [Pubmed]
Induction of neurogenic tumors by nitrosotrialkylureas in rats. Lijinsky, W., Taylor, H.W. Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology. (1975) [Pubmed]
The carcinogenic effect of 1,1-diethyl-3-methyl-3-nitrosourea in European hamsters. Ketkar, M.B., Althoff, J., Lijinsky, W. Experimental pathology. (1981) [Pubmed]

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