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Chemical Compound Review

Confront     2-(3,5,6-trichloropyridin-2- yl)oxyethanoic...

Synonyms: TRICLOPYR, Turflon, Garlon, Redeem, Remedy, ...
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Disease relevance of Turflon

  • Interestingly, our correlation analysis revealed a remarkably strong correlation between beta C+ Ki MAO-A values and their toxicity to PC12 LDH release (r = -0.84) or PC12 protein loss (r = 0.79) [1].
  • Five of these volunteers later received dermal applications of Garlon 4 herbicide formulation equivalent to 3.7 mg triclopyr/kg body weight applied to the forearm [2].
  • Infarct size also correlated with maximal LC II level (r = 0.77), and LC II level 24 hours after coronary occlusion (r = 0.69) [3].

High impact information on Turflon


Analytical, diagnostic and therapeutic context of Turflon

  • A similar dose level was repeated 20 minutes before ligation release (R) [6].


  1. Methyl-beta-carbolinium analogs of MPP+ cause nigrostriatal toxicity after substantia nigra injections in rats. Neafsey, E.J., Albores, R., Gearhart, D., Kindel, G., Raikoff, K., Tamayo, F., Collins, M.A. Brain Res. (1995) [Pubmed]
  2. Oral and dermal pharmacokinetics of triclopyr in human volunteers. Carmichael, N.G., Nolan, R.J., Perkins, J.M., Davies, R., Warrington, S.J. Human toxicology. (1989) [Pubmed]
  3. Assessment of myocardial infarct size by serial changes in serum cardiac myosin light chain II in dogs. Nagai, R., Yazaki, Y. Jpn. Circ. J. (1981) [Pubmed]
  4. Nitric oxide metabolism in canine sepsis: relation to regional blood flow. Tanigawa, K., Bellomo, R., Kellum, J.A., Kim, Y.M., Zar, H., Lancaster, J.R., Pinsky, M.R., Ondulick, B. Journal of critical care. (1999) [Pubmed]
  5. Relationship between serum total cholesterol, infarct size, and early clinical outcome following acute myocardial infarction. Becker, R.C., Corrao, J.M., Lew, R., Bradley, J., Queenan, J. Cardiology (1992) [Pubmed]
  6. Action of amiodarone over the extension and reversibility of experimental myocardial infarction in pigs. Alvarez, C.B., Castelli, A., Grassi, E., Celener, D., Rapapport, M., Martín, J. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. (1984) [Pubmed]
  7. Teratology and reproduction studies with triclopyr in the rat and rabbit. Hanley, T.R., Thompson, D.J., Palmer, A.K., Beliles, R.P., Schwetz, B.A. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1984) [Pubmed]
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