Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L26KP N-ethyl-9-(4-methoxy-2,3,6- trimethyl...

Synonyms: 5239-24-7

Reiners, J. et al., Mezick, J.A. et al., Kistler, A., Marks, R. et al.

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Disease relevance of Motretinide

We investigated both tretinoin and motretinide in normal subjects and in patients with ichthyosis [1].

High impact information on Motretinide

All-trans-retinoic acid was 3.7x, 12.5x, and 50x more potent than 13-cis-retinoic acid, etretinate, and motretinide, respectively, after topical administration [2].
The transplacental pharmacokinetics of single teratogenic doses of etretinate and motretinide were compared with particular emphasis on distribution and concentrations in the exposed embryos of the free acid metabolite, etretin [3].
In contrast, the ethylester analog etretinate was slightly active and the ethylamine analog motretinide inactive in vitro but both were teratogenic in vivo [4].

References

Techniques for assessing the activity of topically applied retinoids. Marks, R., Black, D., Pearse, A.D., Hill, S. J. Am. Acad. Dermatol. (1986) [Pubmed]
Topical and systemic effects of retinoids on horn-filled utriculus size in the rhino mouse. A model to quantify "antikeratinizing" effects of retinoids. Mezick, J.A., Bhatia, M.C., Capetola, R.J. J. Invest. Dermatol. (1984) [Pubmed]
Transplacental pharmacokinetics of teratogenic doses of etretinate and other aromatic retinoids in mice. Reiners, J., Löfberg, B., Kraft, J.C., Kochhar, D.M., Nau, H. Reprod. Toxicol. (1988) [Pubmed]
Limb bud cell cultures for estimating the teratogenic potential of compounds. Validation of the test system with retinoids. Kistler, A. Arch. Toxicol. (1987) [Pubmed]

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