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MeSH Review

Administration, Topical

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  • The present studies show that topical administration of TGF-alpha or VGF in antibiotic cream to partial thickness burns (second degree) accelerated epidermal regeneration in comparison with untreated or vehicle-treated burns [7].
  • GoH3 also reduced the accumulation of DCs in draining lymph nodes by a maximum of 70% after topical administration of the chemical allergen oxazolone [8].
  • After topical administration of U66985 (1 microgram/ml), a putative PAF antagonist, responses to PAF were attenuated significantly, but responses to norepinephrine and U46619 were unchanged [9].
  • Changes in arteriolar luminal diameters in response to topical administration of vasoactive agents were quantified with an image-shearing measuring eyepiece in conjunction with a television microscope and recorder [10].
  • We have reported previously that topical administration of vascular endothelial growth factor165 (VEGF) to a microvascular bed supplied with a continuous endothelium can rapidly induce the formation of endothelial fenestrations (W. G. Roberts and G. E. Palade, J. Cell Sci., 108: 2369-2379, 1995) [11].

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Analytical, diagnostic and therapeutic context of Administration, Topical


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  3. More antibody with less antigen: can immunogenicity of attenuated live virus vaccines be improved? Bukreyev, A., Skiadopoulos, M.H., McAuliffe, J., Murphy, B.R., Collins, P.L., Schmidt, A.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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  5. Halofuginone inhibition of COL1A2 promoter activity via a c-Jun-dependent mechanism. McGaha, T.L., Kodera, T., Spiera, H., Stan, A.C., Pines, M., Bona, C.A. Arthritis Rheum. (2002) [Pubmed]
  6. Duplex Doppler ultrasound assessment of clitoral hemodynamics after topical administration of alprostadil in women with arousal and orgasmic disorders. Bechara, A., Bertolino, M.V., Casabé, A., Munarriz, R., Goldstein, I., Morin, A., Secin, F., Literat, B., Pesaresi, M., Fredotovich, N. Journal of sex & marital therapy. (2003) [Pubmed]
  7. Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor. Schultz, G.S., White, M., Mitchell, R., Brown, G., Lynch, J., Twardzik, D.R., Todaro, G.J. Science (1987) [Pubmed]
  8. Alpha 6 integrins are required for Langerhans cell migration from the epidermis. Price, A.A., Cumberbatch, M., Kimber, I., Ager, A. J. Exp. Med. (1997) [Pubmed]
  9. Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. Armstead, W.M., Pourcyrous, M., Mirro, R., Leffler, C.W., Busija, D.W. Circ. Res. (1988) [Pubmed]
  10. Inhibition of bradykinin vasodilation and potentiation of norepinephrine and angiotensin vasoconstriction by inhibitors of prostaglandin synthesis in skeletal muscle of the rat. Messina, E.J., Weiner, R., Kaley, G. Circ. Res. (1975) [Pubmed]
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  13. Severe anaphylactic reaction to topical administration of framycetin. Proebstle, T.M., Jugert, F.K., Merk, H.F., Gall, H. J. Allergy Clin. Immunol. (1995) [Pubmed]
  14. Cytoplasmic deposition of NFkappaB decoy oligonucleotides is insufficient to inhibit bleomycin-induced pulmonary inflammation. Griesenbach, U., Cassady, R.L., Cain, R.J., duBois, R.M., Geddes, D.M., Alton, E.W. Gene Ther. (2002) [Pubmed]
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  16. Synthesis of (E)-1-(5-chlorothien-2-yl)-2-(1H-imidazol-1-yl)ethanone 2,6-dichlorophenylhydrazone hydrochloride, a novel, orally active antifungal agent. Dyer, R.L., Ellames, G.J., Hamill, B.J., Manley, P.W., Pope, A.M. J. Med. Chem. (1983) [Pubmed]
  17. Effects of topically delivered benzamil and amiloride on nasal potential difference in cystic fibrosis. Hofmann, T., Stutts, M.J., Ziersch, A., Rückes, C., Weber, W.M., Knowles, M.R., Lindemann, H., Boucher, R.C. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  18. Effects of topical nipradilol, a beta-blocking agent with alpha-blocking and nitroglycerin-like activities, on aqueous humor dynamics and fundus circulation. Kanno, M., Araie, M., Tomita, K., Sawanobori, K. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  19. New approaches to influenza chemotherapy. Neuraminidase inhibitors. Calfee, D.P., Hayden, F.G. Drugs (1998) [Pubmed]
  20. Mild hypothermia can enhance pial arteriolar vasodilation induced by isoflurane and sevoflurane in cats. Inoue, S., Kawaguchi, M., Kurehara, K., Sakamoto, T., Kishi, K., Einaga, T., Kitaguchi, K., Furuya, H. Crit. Care Med. (2002) [Pubmed]
  21. Topical verapamil and episcleral venous pressure. Abreu, M.M., Kim, Y.Y., Shin, D.H., Netland, P.A. Ophthalmology (1998) [Pubmed]
  22. Cytokine expression after the topical administration of substance P to human nasal mucosa. The role of substance P in nasal allergy. Okamoto, Y., Shirotori, K., Kudo, K., Ishikawa, K., Ito, E., Togawa, K., Saito, I. J. Immunol. (1993) [Pubmed]
  23. Application of microdialysis for the determination of muscle and subcutaneous tissue concentrations after oral and topical ibuprofen administration. Tegeder, I., Muth-Selbach, U., Lötsch, J., Rüsing, G., Oelkers, R., Brune, K., Meller, S., Kelm, G.R., Sörgel, F., Geisslinger, G. Clin. Pharmacol. Ther. (1999) [Pubmed]
  24. Effect of LTD4 on conjunctival vasopermeability and blood-aqueous barrier integrity. Woodward, D.F., Ledgard, S.E. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  25. Dexmedetomidine-induced ocular hypotension in rabbits with normal or elevated intraocular pressures. Vartiainen, J., MacDonald, E., Urtti, A., Rouhiainen, H., Virtanen, R. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  26. Relative lack of systemic effects of mometasone furoate on Langerhans cells of mice after topical administration as compared with other glucocorticosteroids. Belsito, D.V., Baer, R.L., Schultz, J.M., Thorbecke, G.J. J. Invest. Dermatol. (1988) [Pubmed]
  27. Effects of route of administration and dose on the carcinogenicity of N-nitrosodiethanolamine in the Syrian golden hamster. Hoffman, D., Rivenson, A., Adams, J.D., Juchatz, A., Vinchkoski, N., Hecht, S.S. Cancer Res. (1983) [Pubmed]
  28. Effects of oral versus topical administration of cyclosporine on phorbol ester promotion of murine epidermal carcinogenesis. Yokota, K., Gill, T.J., Shinozuka, H. Cancer Res. (1989) [Pubmed]
  29. Comparative activity of dietary or topical exposure to three retinoids in the promotion of skin tumor induction in mice. McCormick, D.L., Bagg, B.J., Hultin, T.A. Cancer Res. (1987) [Pubmed]
  30. Early induction of rat colonic epithelial ornithine and S-adenosyl-L-methionine decarboxylase activities by N-methyl-N'-nitro-N-nitrosoguanidine or bile salts. Takano, S., Matsushima, M., Ertürk, E., Bryan, G.T. Cancer Res. (1981) [Pubmed]
  31. Diclofenac concentrations in defined tissue layers after topical administration. Müller, M., Mascher, H., Kikuta, C., Schäfer, S., Brunner, M., Dorner, G., Eichler, H.G. Clin. Pharmacol. Ther. (1997) [Pubmed]
  32. Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation. Mascia, F., Mariani, V., Girolomoni, G., Pastore, S. Am. J. Pathol. (2003) [Pubmed]
  33. A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. Fray, M.J., Dickinson, R.P., Huggins, J.P., Occleston, N.L. J. Med. Chem. (2003) [Pubmed]
  34. Recombinant hepatocyte growth factor accelerates cutaneous wound healing in a diabetic mouse model. Yoshida, S., Matsumoto, K., Tomioka, D., Bessho, K., Itami, S., Yoshikawa, K., Nakamura, T. Growth Factors (2004) [Pubmed]
  35. Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions. Ilies, M., Supuran, C.T., Scozzafava, A., Casini, A., Mincione, F., Menabuoni, L., Caproiu, M.T., Maganu, M., Banciu, M.D. Bioorg. Med. Chem. (2000) [Pubmed]
  36. Single topical application of human recombinant basic fibroblast growth factor (rbFGF) promotes neovascularization in rat cerebral cortex. Cuevas, P., Giménez-Gallego, G., Carceller, F., Cuevas, B., Crespo, A. Surgical neurology. (1993) [Pubmed]
  37. A fast, simple reactivation method for the study of HSV-1 latency in the rabbit ocular model. Gordon, Y.J., Romanowski, E., Araullo-Cruz, T. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  38. Comparison of the effects of timolol and other adrenergic agents on intraocular pressure in the rabbit. Vareilles, P., Silverstone, D., Plazonnet, B., Le Douarec, J.C., Sears, M.L., Stone, C.A. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
  39. Effects of topical administration of a bisphosphonate (risedronate) on orthodontic tooth movements in rats. Adachi, H., Igarashi, K., Mitani, H., Shinoda, H. J. Dent. Res. (1994) [Pubmed]
  40. Specific response of mouse tumor-feeding arterioles to stimulation by 5-HT1 agonists. Stücker, O., Laemmel, E., Teisseire, B., Vicaut, E. Int. J. Radiat. Oncol. Biol. Phys. (1997) [Pubmed]
  41. A model for the study of coronary spasm induced changes in cardiac metabolism. Burger, W., Chemnitius, J.M., Metz, M.Z., Bing, R.J. J. Mol. Cell. Cardiol. (1985) [Pubmed]
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