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Chemical Compound Review

Lindleyin     [(2R,3S,4S,5R,6S)-3,4,5- trihydroxy-6-[4-(3...

Synonyms: LS-38403, BRN 1672532, AC1L28Y7, 59282-56-3
 
 
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High impact information on Lindleyin

  • 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of lindleyin [1].
  • The phytochemical lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ERalpha and ERbeta [1].
  • A cDNA encoding BAS was for the first time cloned and sequenced from rhubarb (Rheum palmatum), a medicinal plant rich in phenylbutanoids including pharmaceutically important phenylbutanone glucoside, lindleyin [2].
  • As a result of multiple regression analysis, significant multiple correlation coefficient for antioxidative activities on LDL (R=0.914, P<0.01) was found in relation to the concentrations of five components: aloe-emodin, chrysophanol, emodin 1-O-beta-D-glucoside, lindleyin and 6-hydroxymusizin 8-O-beta-D-glucoside [3].

References

  1. The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors. Usui, T., Ikeda, Y., Tagami, T., Matsuda, K., Moriyama, K., Yamada, K., Kuzuya, H., Kohno, S., Shimatsu, A. J. Endocrinol. (2002) [Pubmed]
  2. Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum. Abe, I., Takahashi, Y., Morita, H., Noguchi, H. Eur. J. Biochem. (2001) [Pubmed]
  3. Evaluation of Rhubarb using antioxidative activity as an index of pharmacological usefulness. Iizuka, A., Iijima, O.T., Kondo, K., Itakura, H., Yoshie, F., Miyamoto, H., Kubo, M., Higuchi, M., Takeda, H., Matsumiya, T. Journal of ethnopharmacology. (2004) [Pubmed]
 
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