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Chemical Compound Review

EMODINE     1,8-dihydroxy-3- (hydroxymethyl)anthracene...

Synonyms: Aloeemodin, Rhabarberone, Aloe-emodin, Aloe-emodine, aloe emodine, ...
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Disease relevance of emodin


High impact information on emodin


Chemical compound and disease context of emodin


Biological context of emodin


Anatomical context of emodin


Associations of emodin with other chemical compounds


Gene context of emodin


Analytical, diagnostic and therapeutic context of emodin


  1. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Pecere, T., Gazzola, M.V., Mucignat, C., Parolin, C., Vecchia, F.D., Cavaggioni, A., Basso, G., Diaspro, A., Salvato, B., Carli, M., Palù, G. Cancer Res. (2000) [Pubmed]
  2. Release of nucleophosmin from the nucleus: Involvement in aloe-emodin-induced human lung non small carcinoma cell apoptosis. Lee, H.Z., Wu, C.H., Chang, S.P. Int. J. Cancer (2005) [Pubmed]
  3. Inactivation of enveloped viruses by anthraquinones extracted from plants. Sydiskis, R.J., Owen, D.G., Lohr, J.L., Rosler, K.H., Blomster, R.N. Antimicrob. Agents Chemother. (1991) [Pubmed]
  4. Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell. Lee, H.Z. Br. J. Pharmacol. (2001) [Pubmed]
  5. Effect of anthraquinone-laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Schörkhuber, M., Richter, M., Dutter, A., Sontag, G., Marian, B. Eur. J. Cancer (1998) [Pubmed]
  6. Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes. Wölfle, D., Schmutte, C., Westendorf, J., Marquardt, H. Cancer Res. (1990) [Pubmed]
  7. In vitro studies on the photobiological properties of aloe emodin and aloin A. Wamer, W.G., Vath, P., Falvey, D.E. Free Radic. Biol. Med. (2003) [Pubmed]
  8. Evaluation of the anti-angiogenic effect of aloe-emodin. C??rdenas, C., Quesada, A.R., Medina, M.A. Cell. Mol. Life Sci. (2006) [Pubmed]
  9. Characterization of the genotoxicity of anthraquinones in mammalian cells. Mueller, S.O., Stopper, H. Biochim. Biophys. Acta (1999) [Pubmed]
  10. Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. Acevedo-Duncan, M., Russell, C., Patel, S., Patel, R. Int. Immunopharmacol. (2004) [Pubmed]
  11. Aloe-emodin prevents cytokine-induced tumor cell death: the inhibition of auto-toxic nitric oxide release as a potential mechanism. Mijatovic, S., Maksimovic-Ivanic, D., Radovic, J., Popadic, D., Momcilovic, M., Harhaji, L., Miljkovic, D., Trajkovic, V. Cell. Mol. Life Sci. (2004) [Pubmed]
  12. Genotoxicity of aloeemodin in vitro and in vivo. Heidemann, A., Völkner, W., Mengs, U. Mutat. Res. (1996) [Pubmed]
  13. Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. Yeh, F.T., Wu, C.H., Lee, H.Z. Int. J. Cancer (2003) [Pubmed]
  14. Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. Chen, H.C., Hsieh, W.T., Chang, W.C., Chung, J.G. Food Chem. Toxicol. (2004) [Pubmed]
  15. The genotoxicity status of senna. Heidemann, A., Miltenburger, H.G., Mengs, U. Pharmacology (1993) [Pubmed]
  16. Cytotoxic and DNA damage-inducing activities of low molecular weight phenols from rhubarb. Shi, Y.Q., Fukai, T., Sakagami, H., Kuroda, J., Miyaoka, R., Tamura, M., Yoshida, N., Nomura, T. Anticancer Res. (2001) [Pubmed]
  17. Optimized separation of pharmacologically active anthraquinones in Rhubarb by capillary electrochromatography. Li, Y., Liu, H., Ji, X., Li, J. Electrophoresis (2000) [Pubmed]
  18. Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1. van Gorkom, B.A., Timmer-Bosscha, H., de Jong, S., van der Kolk, D.M., Kleibeuker, J.H., de Vries, E.G. Br. J. Cancer (2002) [Pubmed]
  19. Ethanol and aloe emodin alter the p53 mutational spectrum in ultraviolet radiation-induced murine skin tumors. Badgwell, D.B., Walker, C.M., Baker, W.T., Strickland, F.M. Mol. Carcinog. (2004) [Pubmed]
  20. Determination of five anthraquinones in medicinal plants by capillary zone electrophoresis with beta-cyclodextrin addition. Tian, K., Zhang, H., Chen, X., Hu, Z. Journal of chromatography. A. (2006) [Pubmed]
  21. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. Lin, J.G., Chen, G.W., Li, T.M., Chouh, S.T., Tan, T.W., Chung, J.G. J. Urol. (2006) [Pubmed]
  22. The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Kuo, P.L., Lin, T.C., Lin, C.C. Life Sci. (2002) [Pubmed]
  23. Analytics of senna drugs with regard to the toxicological discussion of anthranoids. Grimminger, W., Witthohn, K. Pharmacology (1993) [Pubmed]
  24. Determination of the anthraquinones aloe-emodin and aloin-A by liquid chromatography with mass spectrometric and diode array detection. Elsohly, M.A., Gul, W., Avula, B., Khan, I.A. Journal of AOAC International (2007) [Pubmed]
  25. Aloe-emodin induced DNA damage through generation of reactive oxygen species in human lung carcinoma cells. Lee, H.Z., Lin, C.J., Yang, W.H., Leung, W.C., Chang, S.P. Cancer Lett. (2006) [Pubmed]
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