Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Curatrem 4-amino-6-(1,2,2- trichloroethenyl)benzene...

Synonyms: CLORSULON, Clorsulone, Clorsulonum, Ivomec-F, Curatrem (TN), ...

Schulman, M.D. et al., Schulman, M.D. et al., Chiu, S.H. et al.

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High impact information on MK 401

Mechanism of action of MK-401 against Fasciola hepatica: inhibition of phosphoglycerate kinase [1].
ATP, 1,3-diphosphoglycerate and MK-401 protected the Fasciola enzyme from inhibition by N-ethylmaleimide [1].
Dose-dependent pharmacokinetics and efficacy of MK-401 against old, and young-mature infections of Fasciola hepatica in the rat [2].
Fractionation of the host's blood after administration of 14C-MK-401 (0.77-15.8 mg/kg) showed that MK-401 was bound predominately to erythrocytes at doses below 4 mg/kg and at higher doses was distributed equally between the red cells and the plasma [2].

Analytical, diagnostic and therapeutic context of MK 401

Application of carbonic anhydrase affinity chromatography in study of tissue-bound residue of 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide (MK-401, clorsulon) [3].

References

Mechanism of action of MK-401 against Fasciola hepatica: inhibition of phosphoglycerate kinase. Schulman, M.D., Ostlind, D.A., Valentino, D. Mol. Biochem. Parasitol. (1982) [Pubmed]
Dose-dependent pharmacokinetics and efficacy of MK-401 against old, and young-mature infections of Fasciola hepatica in the rat. Schulman, M.D., Valentino, D., Cifelli, S., Ostlind, D.A. J. Parasitol. (1982) [Pubmed]
Application of carbonic anhydrase affinity chromatography in study of tissue-bound residue of 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide (MK-401, clorsulon). Chiu, S.H., Sestokas, E., Taub, R., Walker, R.W., Lu, A.Y. Drug Metab. Dispos. (1985) [Pubmed]

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