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Chemical Compound Review

P-glyceroyl-P     (2-hydroxy-2- phosphonooxycarbonyl...

Synonyms: CHEMBL2074701, HMDB01270, AR-1J1201, AC1L19SB, AC1Q68Q2, ...
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  • That the synthesis of ppppG is catalyzed by PGK itself and not by a contaminant was shown because it depended on 3-phosphoglycerate (as a source of 1,3-bisphosphoglycerate), coeluted with PGK activity upon gel filtration, and the thermal inactivation of the PGK and the ppppG synthetic activity were parallel [23].


  1. Characterization of native and recombinant A4 glyceraldehyde 3-phosphate dehydrogenase. Kinetic evidence for confromation changes upon association with the small protein CP12. Graciet, E., Lebreton, S., Camadro, J.M., Gontero, B. Eur. J. Biochem. (2003) [Pubmed]
  2. Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis. Shi, Y., Vaden, D.L., Ju, S., Ding, D., Geiger, J.H., Greenberg, M.L. J. Biol. Chem. (2005) [Pubmed]
  3. High glucose regulates the activity of cardiac sarcolemmal ATP-sensitive K+ channels via 1,3-bisphosphoglycerate: a novel link between cardiac membrane excitability and glucose metabolism. Jovanović, S., Jovanović, A. Diabetes (2005) [Pubmed]
  4. The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library. Drew, M.E., Morris, J.C., Wang, Z., Wells, L., Sanchez, M., Landfear, S.M., Englund, P.T. J. Biol. Chem. (2003) [Pubmed]
  5. Metabolism of 3-phosphoglyceroyl phosphate in phosphoenolpyruvate-enriched human erythrocytes. Inoue, H., Moriyasu, M., Hamasaki, N. J. Biol. Chem. (1987) [Pubmed]
  6. Glyceraldehyde 3-phosphate dehydrogenase serves as an accessory protein of the cardiac sarcolemmal K(ATP) channel. Jovanović, S., Du, Q., Crawford, R.M., Budas, G.R., Stagljar, I., Jovanović, A. EMBO Rep. (2005) [Pubmed]
  7. Transient and equilibrium kinetic studies on yeast 3-phosphoglycerate kinase. Evidence that an intermediate containing 1,3-bisphosphoglycerate accumulates in the steady state. Schmidt, P.P., Travers, F., Barman, T. Biochemistry (1995) [Pubmed]
  8. Interaction of phosphate analogues with glyceraldehyde-3-phosphate dehydrogenase. Byers, L.D., She, H.S., Alayoff, A. Biochemistry (1979) [Pubmed]
  9. Yeast glyceraldehyde-3-phosphate dehydrogenase. Evidence that subunit cooperativity in catalysis can be controlled by the formation of a complex with phosphoglycerate kinase. Ashmarina, L.I., Muronetz, V.I., Nagradova, N.K. Eur. J. Biochem. (1985) [Pubmed]
  10. The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions. Rodriguez, C.E., Fukuto, J.M., Taguchi, K., Froines, J., Cho, A.K. Chem. Biol. Interact. (2005) [Pubmed]
  11. Studies on the mechanism of inhibition of the red cell metabolism by cardiac glycosides. Okonkwo, P.O., Longenecker, G., Askari, A. J. Pharmacol. Exp. Ther. (1975) [Pubmed]
  12. A study on the complexes between human erythrocyte enzymes participating in the conversions of 1,3-diphosphoglycerate. Fokina, K.V., Dainyak, M.B., Nagradova, N.K., Muronetz, V.I. Arch. Biochem. Biophys. (1997) [Pubmed]
  13. Changes in enzyme activities involved in the degradation of 1,3-bisphosphoglycerate during erythropoiesis in rat bone marrow. Pineda, M., Pinilla, M., Luque, J. Cell Biochem. Funct. (1984) [Pubmed]
  14. Crystal structures of substrates and products bound to the phosphoglycerate kinase active site reveal the catalytic mechanism. Bernstein, B.E., Hol, W.G. Biochemistry (1998) [Pubmed]
  15. The "phosphoryl-enzyme" from phosphoglycerate kinase. Johnson, P.E., Abbott, S.J., Knowles, J.R. Biochemistry (1976) [Pubmed]
  16. Glyceraldehyde-3-phosphate dehydrogenase in neurodegeneration and apoptosis signaling. Tatton, W.G., Chalmers-Redman, R.M., Elstner, M., Leesch, W., Jagodzinski, F.B., Stupak, D.P., Sugrue, M.M., Tatton, N.A. J. Neural Transm. Suppl. (2000) [Pubmed]
  17. Reductive modification and nonreductive activation of purified spinach chloroplast NADP-dependent glyceraldehyde-3-phosphate dehydrogenase. Baalmann, E., Backhausen, J.E., Rak, C., Vetter, S., Scheibe, R. Arch. Biochem. Biophys. (1995) [Pubmed]
  18. Subunit structure and multifunctional properties of yeast phosphoglyceromutase. Sasaki, R., Utsumi, S., Sugimoto, E., Chiba, H. Eur. J. Biochem. (1976) [Pubmed]
  19. Phosphoglycerate kinase deficiency in two brothers with McArdle-like clinical symptoms. Aasly, J., van Diggelen, O.P., Boer, A.M., Brønstad, G. Eur. J. Neurol. (2000) [Pubmed]
  20. A simple screening procedure for glucose phosphate isomerase, phosphofructokinase, aldolase and glyceraldehyde-3-phosphate dehydrogenase deficiencies. Vaca, G., Medina, C., Wunsch, C., Garcia-Cruz, D., Sanchez-Corona, J., Gonzalez-Quiroga, G., Cantu, J.M. Ann. Genet. (1981) [Pubmed]
  21. A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. Bernstein, B.E., Williams, D.M., Bressi, J.C., Kuhn, P., Gelb, M.H., Blackburn, G.M., Hol, W.G. J. Mol. Biol. (1998) [Pubmed]
  22. Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin. Brookes, P.S., Land, J.M., Clark, J.B., Heales, S.J. FEBS Lett. (1997) [Pubmed]
  23. Phosphoglycerate kinase from yeast synthesizes guanosine 5'-tetraphosphate. García-Díaz, M., Canales, J., Sillero, M.A., Sillero, A., Cameselle, J.C. Biochem. Int. (1989) [Pubmed]
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