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Chemical Compound Review

Orpanoxin     3-[5-(4-chlorophenyl)-2- furyl]-3-hydroxy...

Synonyms: Orpanoxine, Orpanoxino, Orpanoxinum, SureCN44039, CHEMBL2107141, ...
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Disease relevance of Orpanoxin

  • Orpanoxin, a nonsteroidal anti-inflammatory drug (NSAID) lacking gastric ulcerogenic effects in the therapeutic dose range in rats, was compared with six reference NSAIDs for oral activity in the rat paw carrageenin-induced edema assay [1].
  • In the guinea-pig u.v.-induced erythema model, application (1 h after u.v.) of 1, 5, and 10% (w/v) orpanoxin creams (containing 10% urea) significantly inhibited erythema at 2, 3, and 4 h post-irradiation [1].

High impact information on Orpanoxin

  • Effects of orpanoxin on arachidonic acid metabolism of human polymorphonuclear leucocytes and platelets in vitro [2].
  • 4. These results indicate that the discrepancy between the low potency of orpanoxin in inhibiting bovine seminal vesicle cyclo-oxygenase in vitro and its high potency as an anti-inflammatory agent in vivo is not explained by its having an additional lipoxygenase inhibitory mechanism [2].
  • It was concluded that orpanoxin has anti-inflammatory activity comparable to reference NSAIDs in the rat paw edema test, is active orally in rat, mouse, and guinea-pig models, and shows topical activity in the guinea-pig and the mouse [1].
  • In comparison, exposure of hepatocytes to the highest dose of orpanoxin resulted only in increased vacuolation, a slight increase in cellular debris, and increased electron density of the cytoplasm of hepatocytes [3].


  1. Anti-inflammatory activity of orpanoxin administered orally and topically to rodents. Brooks, R.R., Bonk, K.R., Decker, G.E., Miller, K.E. Agents Actions (1985) [Pubmed]
  2. Effects of orpanoxin on arachidonic acid metabolism of human polymorphonuclear leucocytes and platelets in vitro. Doerr, I.L., Kaufman, J., Brooks, R.R. Clin. Exp. Pharmacol. Physiol. (1988) [Pubmed]
  3. Relative toxicities of several nonsteroidal antiinflammatory compounds in primary cultures of rat hepatocytes. Sorensen, E.M., Acosta, D. Journal of toxicology and environmental health. (1985) [Pubmed]
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