Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1N8NIU 8-aminopyrene-1,3,6- trisulfonic acid

Synonyms: CTK1G3652, 51987-58-7, 8-aminopyrene-1,3,6-trisulfonic Acid, 1,3,6-Pyrenetrisulfonic acid, 8-amino-

Ma, S. et al., Callewaert, N. et al.

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High impact information on 8-aminopyrene-1,3,6-trisulfonic acid

We implemented 8-aminopyrene-1,3,6-trisulfonic acid (APTS)-labeled asparagine-linked glycan (N-glycan) profiling on a microfluidic electrophoresis platform [1].
To monitor the variation of the glycosylation during manufacture, the glycans were first enzymatically released from the antibody via digestion with peptide-N-glycosidase F, then derivatized with a charged fluorophore, 8-aminopyrene-1,3,6-trisulfonic acid and further separated by capillary electrophoresis with laser-induced fluorescence detection [2].

References

Total serum protein N-glycome profiling on a capillary electrophoresis-microfluidics platform. Callewaert, N., Contreras, R., Mitnik-Gankin, L., Carey, L., Matsudaira, P., Ehrlich, D. Electrophoresis (2004) [Pubmed]
Carbohydrate analysis of a chimeric recombinant monoclonal antibody by capillary electrophoresis with laser-induced fluorescence detection. Ma, S., Nashabeh, W. Anal. Chem. (1999) [Pubmed]

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