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Chemical Compound Review:

BSPBio_002608 2-[(2-formamido-4- methylsulfanyl...

Synonyms: KBioGR_001887, KBioSS_001798, CCG-40320, NINDS_000498, SPBio_001265, ...

Bokoch, G.M. et al., Gray, G.D. et al., Grant, M.M. et al., Radermecker, M. et al.

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High impact information on N-formylmethionylphenylalanine

The ability of N-formylmethionylphenylalanine to stimulate arachidonic acid metabolism of polymorphonuclear leukocytes was specifically antagonized by a competitive blocker of the formylated peptide receptor, t-butoxy-carbonyl-leucyl-phenylalanyl-leucyl-phenylalanine [1].
IL-3 had a comparable enhancing effect when basophils were triggered with anti-IgE or N-formylmethionylphenylalanine (FMP) [2].
However, no response was obtained to N-formylmethionylleucylphenylalanine (FMLP), and four similar peptides that activate the FMLP receptor (N-formylnorleucylleucylphenylalanine, N-formylmethionylphenylalanine, methionylleucylphenylalanine, and pepstatin) [3].
Particles and irritant stimuli (Fe2O3, endotoxin, and N-formylmethionylphenylalanine) elicited only eosinophilic granulocytes that were not phagocytic [4].

References

Stimulation of arachidonic acid metabolism in the polymorphonuclear leukocyte by an N-formylated peptide. Comparison with ionophore A23187. Bokoch, G.M., Reed, P.W. J. Biol. Chem. (1980) [Pubmed]
Cytokine modulation of basophil histamine release in wasp-venom allergy. Radermecker, M., Louis, R., Leclercq, M., Weber, T., Corhay, J.L., Bury, T. Allergy (1994) [Pubmed]
Feline polymorphonuclear leukocytes respond chemotactically to leukotriene B4 and activated serum but not to F-Met-Leu-Phe. Gray, G.D., Ohlmann, G.M., Morton, D.R., Schaub, R.G. Agents Actions (1986) [Pubmed]
Pulmonary defense mechanisms in Boa constrictor. Grant, M.M., Brain, J.D., Vinegar, A. Journal of applied physiology: respiratory, environmental and exercise physiology. (1981) [Pubmed]

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