Gene Review:
FPR1 - formyl peptide receptor 1
Homo sapiens
Synonyms:
FMLP, FPR, N-formyl peptide receptor, N-formylpeptide chemoattractant receptor, fMLP receptor, ...
Ransom,
Jabbour,
Arcangeli,
Broach,
Mills,
Manfredi,
Trueheart,
Sauvé,
Murphy,
Sales,
Fu,
Bylund,
Paul,
Klein,
Brian A. Babbin,
Algirdas J. Jesaitis,
Andrei I. Ivanov,
Daina Kelly,
Mike Laukoetter,
Porfirio Nava,
Charles A. Parkos,
Asma Nusrat,
Karlsson,
Boddy,
Anderson,
Dahlgren,
Pellmé,
Schmidt,
Williams,
- Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. Zhang, Y., Syed, R., Uygar, C., Pallos, D., Gorry, M.C., Firatli, E., Cortelli, J.R., VanDyke, T.E., Hart, P.S., Feingold, E., Hart, T.C. Genes Immun. (2003)
- The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, expression, and structure/function implications. Ye, R.D., Quehenberger, O., Thomas, K.M., Navarro, J., Cavanagh, S.L., Prossnitz, E.R., Cochrane, C.G. J. Immunol. (1993)
- A new staphylococcal anti-inflammatory protein that antagonizes the formyl Peptide receptor-like 1. Prat, C., Bestebroer, J., de Haas, C.J., van Strijp, J.A., van Kessel, K.P. J. Immunol. (2006)
- An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. Ernst, S., Lange, C., Wilbers, A., Goebeler, V., Gerke, V., Rescher, U. J. Immunol. (2004)
- T21/DP107, A synthetic leucine zipper-like domain of the HIV-1 envelope gp41, attracts and activates human phagocytes by using G-protein-coupled formyl peptide receptors. Su, S.B., Gao, J., Gong, W., Dunlop, N.M., Murphy, P.M., Oppenheim, J.J., Wang, J.M. J. Immunol. (1999)
- Induction of the Formyl Peptide Receptor 2 in Microglia by IFN-{gamma} and Synergy with CD40 Ligand. Chen, K., Iribarren, P., Huang, J., Zhang, L., Gong, W., Cho, E.H., Lockett, S., Dunlop, N.M., Wang, J.M. J. Immunol. (2007)
- The sequential release of granule constitutents from human neutrophils. Bentwood, B.J., Henson, P.M. J. Immunol. (1980)
- Electroencephalogram and cardiovascular responses to noise during daytime sleep in shiftworkers. Nicolas, A., Bach, V., Tassi, P., Dewasmes, G., Ehrhart, J., Muzet, A., Libert, J.P. European journal of applied physiology and occupational physiology. (1993)
- Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils. Philips, M.R., Pillinger, M.H., Staud, R., Volker, C., Rosenfeld, M.G., Weissmann, G., Stock, J.B. Science (1993)
- Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Heitman, J., Movva, N.R., Hall, M.N. Science (1991)
- Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Murphy, P.M., Tiffany, H.L. Science (1991)
- A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells. Su, S.B., Gong, W., Gao, J.L., Shen, W., Murphy, P.M., Oppenheim, J.J., Wang, J.M. J. Exp. Med. (1999)
- Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways. Sales, K.J., Milne, S.A., Williams, A.R., Anderson, R.A., Jabbour, H.N. J. Clin. Endocrinol. Metab. (2004)
- High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl Peptide receptor agonists. Schepetkin, I.A., Kirpotina, L.N., Khlebnikov, A.I., Quinn, M.T. Mol. Pharmacol. (2007)
- A positive feedback loop that regulates cyclooxygenase-2 expression and prostaglandin F2alpha synthesis via the F-series-prostanoid receptor and extracellular signal-regulated kinase 1/2 signaling pathway. Jabbour, H.N., Sales, K.J., Boddy, S.C., Anderson, R.A., Williams, A.R. Endocrinology (2005)
- Human platelets exhibit chemotaxis using functional N-formyl peptide receptors. Czapiga, M., Gao, J.L., Kirk, A., Lekstrom-Himes, J. Exp. Hematol. (2005)
- Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1R. Sahagun-Ruiz, A., Colla, J.S., Juhn, J., Gao, J.L., Murphy, P.M., McDermott, D.H. Genes Immun. (2001)
- Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. Durstin, M., Gao, J.L., Tiffany, H.L., McDermott, D., Murphy, P.M. Biochem. Biophys. Res. Commun. (1994)
- A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. Murphy, P.M., Ozçelik, T., Kenney, R.T., Tiffany, H.L., McDermott, D., Francke, U. J. Biol. Chem. (1992)
- Basophils infiltrate human gastric mucosa at sites of Helicobacter pylori infection, and exhibit chemotaxis in response to H. pylori-derived peptide Hp(2-20). de Paulis, A., Prevete, N., Fiorentino, I., Walls, A.F., Curto, M., Petraroli, A., Castaldo, V., Ceppa, P., Fiocca, R., Marone, G. J. Immunol. (2004)
- Expression and function of formyl peptide receptors on human fibroblast cells. VanCompernolle, S.E., Clark, K.L., Rummel, K.A., Todd, S.C. J. Immunol. (2003)
- Activation of the mitogen-activated protein kinase pathway by fMet-leu-Phe in the absence of Lyn and tyrosine phosphorylation of SHC in transfected cells. Torres, M., Ye, R.D. J. Biol. Chem. (1996)
- Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase. Rane, M.J., Carrithers, S.L., Arthur, J.M., Klein, J.B., McLeish, K.R. J. Immunol. (1997)
- Formyl peptide receptors: A promiscuous subfamily of G protein-coupled receptors controlling immune responses. Migeotte, I., Communi, D., Parmentier, M. Cytokine Growth Factor Rev. (2006)
- Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and formyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. Le, Y., Gong, W., Li, B., Dunlop, N.M., Shen, W., Su, S.B., Ye, R.D., Wang, J.M. J. Immunol. (1999)
- Formyl peptide receptor-1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42. Babbin, B.A., Jesaitis, A.J., Ivanov, A.I., Kelly, D., Laukoetter, M., Nava, P., Parkos, C.A., Nusrat, A. J. Immunol. (2007)
- Chemoattractant cross-desensitization of the human neutrophil IL-8 receptor involves receptor internalization and differential receptor subtype regulation. Sabroe, I., Williams, T.J., Hébert, C.A., Collins, P.D. J. Immunol. (1997)
- Peptides derived from HIV-1, HIV-2, Ebola virus, SARS coronavirus and coronavirus 229E exhibit high affinity binding to the formyl peptide receptor. Mills, J.S. Biochim. Biophys. Acta (2006)
- Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases. Graham, T.E., Prossnitz, E.R., Dorin, R.I. J. Biol. Chem. (2002)
- Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. Alemany, R., Meyer zu Heringdorf, D., van Koppen, C.J., Jakobs, K.H. J. Biol. Chem. (1999)
- Differential activation of formyl peptide receptor signaling by peptide ligands. Bae, Y.S., Song, J.Y., Kim, Y., He, R., Ye, R.D., Kwak, J.Y., Suh, P.G., Ryu, S.H. Mol. Pharmacol. (2003)
- The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. Fu, H., Bylund, J., Karlsson, A., Pellmé, S., Dahlgren, C. Immunology (2004)
- Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. Fiore, S., Serhan, C.N. Biochemistry (1995)
- Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast. Klein, C., Paul, J.I., Sauvé, K., Schmidt, M.M., Arcangeli, L., Ransom, J., Trueheart, J., Manfredi, J.P., Broach, J.R., Murphy, A.J. Nat. Biotechnol. (1998)
- The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. Kang, H.K., Lee, H.Y., Kim, M.K., Park, K.S., Park, Y.M., Kwak, J.Y., Bae, Y.S. J. Immunol. (2005)
- Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Bao, L., Gerard, N.P., Eddy, R.L., Shows, T.B., Gerard, C. Genomics (1992)
- Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2. de Paulis, A., Montuori, N., Prevete, N., Fiorentino, I., Rossi, F.W., Visconte, V., Rossi, G., Marone, G., Ragno, P. J. Immunol. (2004)
- Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Ye, R.D., Cavanagh, S.L., Quehenberger, O., Prossnitz, E.R., Cochrane, C.G. Biochem. Biophys. Res. Commun. (1992)
- The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils. Plesner, T., Ploug, M., Ellis, V., Rønne, E., Høyer-Hansen, G., Wittrup, M., Pedersen, T.L., Tscherning, T., Danø, K., Hansen, N.E. Blood (1994)
- Simultaneous mobilization of Mac-1 (CD11b/CD18) and formyl peptide chemoattractant receptors in human neutrophils. Graves, V., Gabig, T., McCarthy, L., Strour, E.F., Leemhuis, T., English, D. Blood (1992)
- Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. Prossnitz, E.R., Kim, C.M., Benovic, J.L., Ye, R.D. J. Biol. Chem. (1995)
- C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil. Richard, S., Farrell, C.A., Shaw, A.S., Showell, H.J., Connelly, P.A. J. Immunol. (1994)