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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Basophils


Psychiatry related information on Basophils


High impact information on Basophils


Chemical compound and disease context of Basophils


Biological context of Basophils


Anatomical context of Basophils


Associations of Basophils with chemical compounds

  • We present a model for the control of immunoglobulin E (IgE)-mediated histamine release from human basophils [25].
  • Both mast cells and basophils possess receptors which bind the Fc portion of IgE with high affinity; crosslinking of membrane-bound IgE by allergen results in degranulation of the cell and release of a variety of pharmacologically active mediator including histamine [26].
  • Mast cells, basophils and a tumour analogue--rat basophilic leukaemia (RBL) cells--have a surface glycoprotein (R epsilon) which specifically binds monomeric immunoglobulin E (IgE), and aggregation of R epsilon causes secretion [27].
  • Basophil variants with impaired cromoglycate binding do not respond to an immunological degranulation stimulus [16].
  • IL-5 enhanced basophil histamine release evoked by anti-IgE, formyl-methionyl-leucyl-phenylalanine, or ionophore A23187 at picomolar concentrations [28].

Gene context of Basophils


Analytical, diagnostic and therapeutic context of Basophils


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  2. Monocyte chemotactic protein 1 is a potent activator of human basophils. Bischoff, S.C., Krieger, M., Brunner, T., Dahinden, C.A. J. Exp. Med. (1992) [Pubmed]
  3. Defective histamine release in chronic urticaria. Kern, F., Lichtenstein, L.M. J. Clin. Invest. (1976) [Pubmed]
  4. Anaphylactic release of a basophil kallikrein-like activity. I. Purification and characterization. Newball, H.H., Berninger, R.W., Talamo, R.C., Lichtenstein, L.M. J. Clin. Invest. (1979) [Pubmed]
  5. Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis. Levine, L., Morgan, R.A., Lewis, R.A., Austen, K.F., Clark, D.A., Marfat, A., Corey, E.J. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
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  10. A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation. Zhu, D., Kepley, C.L., Zhang, M., Zhang, K., Saxon, A. Nat. Med. (2002) [Pubmed]
  11. Basophils (Bsp-1+) derive from the leukemic clone in human myeloid leukemias involving the chromosome breakpoint 9q34. Bodger, M.P., Morris, C.M., Kennedy, M.A., Bowen, J.A., Hilton, J.M., Fitzgerald, P.H. Blood (1989) [Pubmed]
  12. Effect of disodium cromoglycate on cutaneous basophil anaphylaxis. Golden, H.W., Crean, G.L., Iacuzio, D.A., Otterness, I.G. J. Immunol. (1986) [Pubmed]
  13. Role of the clotting system in cell-mediated hypersensitivity. II. Kinetics of fibrinogen/fibrin accumulation and vascular permeability changes in tuberculin and cutaneous basophil hypersensitivity reactions. Colvin, R.B., Dvorak, H.F. J. Immunol. (1975) [Pubmed]
  14. Colonic basophil hypersensitivity. Askenase, P.W., Boone, W.T., Binder, H.J. J. Immunol. (1978) [Pubmed]
  15. Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2. Hartnell, A., Heinemann, A., Conroy, D.M., Wait, R., Sturm, G.J., Caversaccio, M., Jose, P.J., Williams, T.J. J. Immunol. (2004) [Pubmed]
  16. Basophil variants with impaired cromoglycate binding do not respond to an immunological degranulation stimulus. Mazurek, N., Bashkin, P., Petrank, A., Pecht, I. Nature (1983) [Pubmed]
  17. Phospholipid methylation and biological signal transmission. Hirata, F., Axelrod, J. Science (1980) [Pubmed]
  18. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. Hirai, H., Tanaka, K., Yoshie, O., Ogawa, K., Kenmotsu, K., Takamori, Y., Ichimasa, M., Sugamura, K., Nakamura, M., Takano, S., Nagata, K. J. Exp. Med. (2001) [Pubmed]
  19. Fc receptor-mediated phagocytosis requires CDC42 and Rac1. Massol, P., Montcourrier, P., Guillemot, J.C., Chavrier, P. EMBO J. (1998) [Pubmed]
  20. Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase. Yamashita, T., Mao, S.Y., Metzger, H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  21. Inability of the C3a anaphylatoxin to promote cellular lysis. Goodman, M.G., Weigle, W.O., Hugli, T.E. Nature (1980) [Pubmed]
  22. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. Sallusto, F., Mackay, C.R., Lanzavecchia, A. Science (1997) [Pubmed]
  23. An interleukin-4-induced transcription factor: IL-4 Stat. Hou, J., Schindler, U., Henzel, W.J., Ho, T.C., Brasseur, M., McKnight, S.L. Science (1994) [Pubmed]
  24. Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils. Kuna, P., Reddigari, S.R., Rucinski, D., Oppenheim, J.J., Kaplan, A.P. J. Exp. Med. (1992) [Pubmed]
  25. A model of cell activation and desensitization by surface immunoglobin: the case of histamine release from human basophils. Dembo, M., Goldstein, B. Cell (1980) [Pubmed]
  26. A hapten-specific chimaeric IgE antibody with human physiological effector function. Neuberger, M.S., Williams, G.T., Mitchell, E.B., Jouhal, S.S., Flanagan, J.G., Rabbitts, T.H. Nature (1985) [Pubmed]
  27. Reaction of 5-iodonaphthyl-1-nitrene with the IgE receptor on normal and tumour mast cells. Holowka, D., Gitler, C., Bercovici, T., Metzger, H. Nature (1981) [Pubmed]
  28. Enhancement of human basophil histamine release by interleukin 5. Hirai, K., Yamaguchi, M., Misaki, Y., Takaishi, T., Ohta, K., Morita, Y., Ito, K., Miyamoto, T. J. Exp. Med. (1990) [Pubmed]
  29. Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation. Brunner, T., Heusser, C.H., Dahinden, C.A. J. Exp. Med. (1993) [Pubmed]
  30. Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine. Dahinden, C.A., Geiser, T., Brunner, T., von Tscharner, V., Caput, D., Ferrara, P., Minty, A., Baggiolini, M. J. Exp. Med. (1994) [Pubmed]
  31. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. Min, B., Prout, M., Hu-Li, J., Zhu, J., Jankovic, D., Morgan, E.S., Urban, J.F., Dvorak, A.M., Finkelman, F.D., LeGros, G., Paul, W.E. J. Exp. Med. (2004) [Pubmed]
  32. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. Uguccioni, M., Mackay, C.R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G.J., Rao, P., Ponath, P.D., Baggiolini, M., Dahinden, C.A. J. Clin. Invest. (1997) [Pubmed]
  33. PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Henkel, G., Brown, M.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  34. Localization of eosinophil granule major basic protein in human basophils. Ackerman, S.J., Kephart, G.M., Habermann, T.M., Greipp, P.R., Gleich, G.J. J. Exp. Med. (1983) [Pubmed]
  35. Interleukin 3-dependent mediator release in basophils triggered by C5a. Kurimoto, Y., de Weck, A.L., Dahinden, C.A. J. Exp. Med. (1989) [Pubmed]
  36. Nasal challenge with ragweed pollen in hay fever patients. Effect of immunotherapy. Creticos, P.S., Adkinson, N.F., Kagey-Sobotka, A., Proud, D., Meier, H.L., Naclerio, R.M., Lichtenstein, L.M., Norman, P.S. J. Clin. Invest. (1985) [Pubmed]
  37. Human blood basophils synthesize interleukin-2 binding sites. Stockinger, H., Valent, P., Majdic, O., Bettelheim, P., Knapp, W. Blood (1990) [Pubmed]
  38. Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms. Samorapoompichit, P., Kiener, H.P., Schernthaner, G.H., Jordan, J.H., Agis, H., Wimazal, F., Baghestanian, M., Rezaie-Majd, A., Sperr, W.R., Lechner, K., Valent, P. Blood (2001) [Pubmed]
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