Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL333886 N-[2-(6-fluoro-5-methoxy-1H- indol-3...

Synonyms: SureCN1772618, SureCN1772619, LS-9627, CHEBI:308142, AC1L2ASC, ...

Franchi, A.M. et al., Clemens, J.A. et al.

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High impact information on 62106-00-7

Melatonin, and its analogs 6-chloro- and 6-fluoromelatonin inhibited in a dose-dependent way (10(-8)-10(-5) M) labeled prostaglandin (PG) E2, PGF2 alpha, thromboxane (Tx) B2 and 6-keto-PGF1 alpha production from [14C]arachidonate by rat medial basal hypothalamus (MBH) [1].
Inhibition of luteinizing hormone release and ovulation by 6-chloro- and 6-fluoromelatonin [2].

References

Melatonin, 5-methoxytryptamine and some of their analogs as cyclo-oxygenase inhibitors in rat medial basal hypothalamus. Franchi, A.M., Gimeno, M.F., Cardinali, D.P., Vacas, M.I. Brain Res. (1987) [Pubmed]
Inhibition of luteinizing hormone release and ovulation by 6-chloro- and 6-fluoromelatonin. Clemens, J.A., Flaugh, M.E., Parli, J., Sawyer, B.D. Neuroendocrinology (1980) [Pubmed]

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