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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1L9842     (2R)-1-[(2R)-2-amino-3- phenyl-propanoyl]-N...

Synonyms: C02828, D-Phe-Pro-Arg-CH2Cl
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High impact information on D-Phe-Pro-Arg-CH2Cl

  • This reduction in binding was also shown using t-PA treated with the chloromethylketone, D-Phe-Pro-Arg-CH2Cl (PPACK) (36% +/- 13%, n = 3), and with S478A, a mutant t-PA in which the active site serine at position 478 has been substituted by alanine (43% +/- 6%, n = 3) [1].
  • Comparison of specific antibody, D-Phe-Pro-Arg-CH2Cl and aprotinin for prevention of in vitro effects of recombinant tissue-type plasminogen activator on haemostasis parameters [2].
  • The tripeptide D-Phe-Pro-Arg-CH2Cl and related tetrapeptide inhibitors inhibit thrombin more potently than factor IXa and plasma kallikrein by 2-5 orders of magnitude [3].
  • The S2238 activity was inhibited by D-Phe-Pro-Arg-CH2Cl, but with an estimated second-order rate constant of 3 X 10(5) mol/L-1 minute-1, approximately 1000 times less than for thrombin [4].

Gene context of D-Phe-Pro-Arg-CH2Cl


Analytical, diagnostic and therapeutic context of D-Phe-Pro-Arg-CH2Cl


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