Gene Review:
PLAT - plasminogen activator, tissue
Homo sapiens
Synonyms:
T-PA, TPA, Tissue-type plasminogen activator, t-PA, t-plasminogen activator, ...
- FGFRI and PLAT genes and DNA amplification at 8p12 in breast and ovarian cancers. Theillet, C., Adelaide, J., Louason, G., Bonnet-Dorion, F., Jacquemier, J., Adnane, J., Longy, M., Katsaros, D., Sismondi, P., Gaudray, P. Genes Chromosomes Cancer (1993)
- Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation with gene expression analysis in endoscopic ultrasound-guided fine needle aspiration samples. Laurell, H., Bouisson, M., Berthelemy, P., Rochaix, P., Dejean, S., Besse, P., Susini, C., Pradayrol, L., Vaysse, N., Buscail, L. World J. Gastroenterol. (2006)
- Cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction. Mark, D.B., Hlatky, M.A., Califf, R.M., Naylor, C.D., Lee, K.L., Armstrong, P.W., Barbash, G., White, H., Simoons, M.L., Nelson, C.L. N. Engl. J. Med. (1995)
- Bolus fibrinolytic therapy in acute myocardial infarction. Llevadot, J., Giugliano, R.P., Antman, E.M. JAMA (2001)
- Tissue-type plasminogen activator (t-PA) is stored in Weibel-Palade bodies in human endothelial cells both in vitro and in vivo. Huber, D., Cramer, E.M., Kaufmann, J.E., Meda, P., Massé, J.M., Kruithof, E.K., Vischer, U.M. Blood (2002)
- Alteplase. A reappraisal of its pharmacological properties and therapeutic use in acute myocardial infarction. Gillis, J.C., Wagstaff, A.J., Goa, K.L. Drugs (1995)
- Risks versus benefits: the alteplase experience. Green, J.A. American journal of hospital pharmacy. (1989)
- Complexing of tissue plasminogen activator with PAI-1, alpha 2-macroglobulin, and C1-inhibitor: studies in patients with defibrination and a fibrinolytic state after electroshock or complicated labor. Bennett, B., Croll, A., Ferguson, K., Booth, N.A. Blood (1990)
- Effects of moderate alcohol consumption on platelet function, tissue-type plasminogen activator and plasminogen activator inhibitor. Veenstra, J., Kluft, C., Ockhuizen, T.H., vd Pol, H., Wedel, M., Schaafsma, G. Thromb. Haemost. (1990)
- Prothrombotic coagulation abnormalities preceding the hemolytic-uremic syndrome. Chandler, W.L., Jelacic, S., Boster, D.R., Ciol, M.A., Williams, G.D., Watkins, S.L., Igarashi, T., Tarr, P.I. N. Engl. J. Med. (2002)
- Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. Schömig, A., Kastrati, A., Dirschinger, J., Mehilli, J., Schricke, U., Pache, J., Martinoff, S., Neumann, F.J., Schwaiger, M. N. Engl. J. Med. (2000)
- AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression. Zeng, Y.X., Somasundaram, K., el-Deiry, W.S. Nat. Genet. (1997)
- Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Thompson, S.G., Kienast, J., Pyke, S.D., Haverkate, F., van de Loo, J.C. N. Engl. J. Med. (1995)
- More rapid, complete, and stable coronary thrombolysis with bolus administration of reteplase compared with alteplase infusion in acute myocardial infarction. RAPID Investigators. Smalling, R.W., Bode, C., Kalbfleisch, J., Sen, S., Limbourg, P., Forycki, F., Habib, G., Feldman, R., Hohnloser, S., Seals, A. Circulation (1995)
- Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro. Barker-Carlson, K., Lawrence, D.A., Schwartz, B.S. J. Biol. Chem. (2002)
- Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells captured by laser microdissection. Liu, X.S., Zhang, Z.G., Zhang, L., Morris, D.C., Kapke, A., Lu, M., Chopp, M. J. Cereb. Blood Flow Metab. (2006)
- On the role of C1-inhibitor as inhibitor of tissue-type plasminogen activator in human plasma. Huisman, L.G., van Griensven, J.M., Kluft, C. Thromb. Haemost. (1995)
- Dinucleotide repeat polymorphism at the human tissue plasminogen activator gene (PLAT). Sadler, L.A., Blanton, S.H., Daiger, S.P. Nucleic Acids Res. (1991)
- Distribution and frequency of a polymorphic Alu insertion at the plasminogen activator locus in humans. Tishkoff, S.A., Ruano, G., Kidd, J.R., Kidd, K.K. Hum. Genet. (1996)
- Genetic variation at the human tissue-type plasminogen activator (tPA) locus: haplotypes and analysis of association to plasma levels of tPA. Ladenvall, P., Nilsson, S., Jood, K., Rosengren, A., Blomstrand, C., Jern, C. Eur. J. Hum. Genet. (2003)
- Linkage mapping of autosomal dominant retinitis pigmentosa (RP1) to the pericentric region of human chromosome 8. Blanton, S.H., Heckenlively, J.R., Cottingham, A.W., Friedman, J., Sadler, L.A., Wagner, M., Friedman, L.H., Daiger, S.P. Genomics (1991)
- Variant tissue-type plasminogen activator (PLAT) cDNA obtained from human endothelial cells. Siebert, P.D., Fong, K. Nucleic Acids Res. (1990)
- Assignment of the human tissue-type plasminogen activator gene (PLAT) to chromosome 8. Verheijen, J.H., Visse, R., Wijnen, J.T., Chang, G.T., Kluft, C., Meera Khan, P. Hum. Genet. (1986)
- Regulation and secretion of plasminogen activators and their inhibitors in a human leukemic cell line (K562). Oliver, L.J., Keeton, M., Wilson, E.L. Blood (1989)
- Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: enhanced expression by macrophages. Brownstein, C., Deora, A.B., Jacovina, A.T., Weintraub, R., Gertler, M., Khan, K.M., Falcone, D.J., Hajjar, K.A. Blood (2004)
- Complementary modes of action of tissue-type plasminogen activator and pro-urokinase by which their synergistic effect on clot lysis may be explained. Pannell, R., Black, J., Gurewich, V. J. Clin. Invest. (1988)
- Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA. Renatus, M., Engh, R.A., Stubbs, M.T., Huber, R., Fischer, S., Kohnert, U., Bode, W. EMBO J. (1997)
- Fibrinolysis inhibits shear stress-induced platelet aggregation. Kamat, S.G., Michelson, A.D., Benoit, S.E., Moake, J.L., Rajasekhar, D., Hellums, J.D., Kroll, M.H., Schafer, A.I. Circulation (1995)
- The circulatory regulation of TPA and UPA secretion, clearance, and inhibition during exercise and during the infusion of isoproterenol and phenylephrine. Chandler, W.L., Levy, W.C., Stratton, J.R. Circulation (1995)
- Vascular smooth muscle cells potentiate plasmin generation by both urokinase and tissue plasminogen activator-dependent mechanisms: evidence for a specific tissue-type plasminogen activator receptor on these cells. Ellis, V., Whawell, S.A. Blood (1997)
- Interaction of wild-type and catalytically inactive mutant forms of tissue-type plasminogen activator with human umbilical vein endothelial cell monolayers. Ramakrishnan, V., Sinicropi, D.V., Dere, R., Darbonne, W.C., Bechtol, K.B., Baker, J.B. J. Biol. Chem. (1990)
- Tissue plasminogen activator and urokinase enhance the binding of plasminogen to thrombospondin. Silverstein, R.L., Harpel, P.C., Nachman, R.L. J. Biol. Chem. (1986)
- The PDC-109 protein from bovine seminal plasma is similar to the gelatin-binding domain of bovine fibronectin and a kringle domain of human tissue-type plasminogen activator. Baker, M.E. Biochem. Biophys. Res. Commun. (1985)
- Prostromelysin-1 (proMMP-3) stimulates plasminogen activation by tissue-type plasminogen activator. Arza, B., Hoylaerts, M.F., Félez, J., Collen, D., Lijnen, H.R. Eur. J. Biochem. (2000)
- Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin. Parkkinen, J., Rauvala, H. J. Biol. Chem. (1991)
- Protonation state of a single histidine residue contributes significantly to the kinetics of the reaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator. Komissarov, A.A., Declerck, P.J., Shore, J.D. J. Biol. Chem. (2004)
- Hepatocyte growth factor plasma levels after myocardial infarction are not affected by recombinant tissue-type plasminogen-activator therapy. Molnar, C., Buratti, T., Wiedermann, C.J., Tilg, H. Eur. Cytokine Netw. (2000)
- 19F NMR studies of plasminogen activator inhibitor-1. Abbott, G.L., Blouse, G.E., Perron, M.J., Shore, J.D., Luck, L.A., Szabo, A.G. Biochemistry (2004)
- Pharmacology and clinical trial results of lanoteplase in acute myocardial infarction. Llevadot, J., Guigliano, R.P. Expert opinion on investigational drugs. (2000)
- Plasminogen activator expression in human atherosclerotic lesions. Lupu, F., Heim, D.A., Bachmann, F., Hurni, M., Kakkar, V.V., Kruithof, E.K. Arterioscler. Thromb. Vasc. Biol. (1995)
- ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. Wen-Sheng, W. Oncogene (2003)
- The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. Dekker, R.J., Eichinger, A., Stoop, A.A., Bode, W., Pannekoek, H., Horrevoets, A.J. J. Mol. Biol. (1999)
- Plasminogen activators play an essential role in extracellular-matrix invasion by lymphoblastic T cells. Reiter, L.S., Spertini, O., Kruithof, E.K. Int. J. Cancer (1997)
- Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. Silverstein, R.L., Leung, L.L., Harpel, P.C., Nachman, R.L. J. Clin. Invest. (1984)
- Imbalance of plasminogen activators and their inhibitors in human colorectal neoplasia. Implications of urokinase in colorectal carcinogenesis. Sier, C.F., Verspaget, H.W., Griffioen, G., Verheijen, J.H., Quax, P.H., Dooijewaard, G., De Bruin, P.A., Lamers, C.B. Gastroenterology (1991)
- High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an independent primary risk factor. Thögersen, A.M., Jansson, J.H., Boman, K., Nilsson, T.K., Weinehall, L., Huhtasaari, F., Hallmans, G. Circulation (1998)
- Chromatin modification of the trefoil factor 1 gene in human breast cancer cells by the Ras/mitogen-activated protein kinase pathway. Espino, P.S., Li, L., He, S., Yu, J., Davie, J.R. Cancer Res. (2006)
- Characterization of chromosome 8 aberrations in the prostate cancer cell line LNCaP-FGC and sublines. König, J.J., Teubel, W., van Steenbrugge, G.J., Romijn, J.C., Hagemeijer, A. Urol. Res. (1999)
- Increased fibrin turnover and high PAI-1 activity as predictors of ischemic events in atherosclerotic patients. A case-control study. The PLAT Group. Cortellaro, M., Cofrancesco, E., Boschetti, C., Mussoni, L., Donati, M.B., Cardillo, M., Catalano, M., Gabrielli, L., Lombardi, B., Specchia, G. Arterioscler. Thromb. (1993)
- Comparisons of characteristics and outcomes among women and men with acute myocardial infarction treated with thrombolytic therapy. GUSTO-I investigators. Weaver, W.D., White, H.D., Wilcox, R.G., Aylward, P.E., Morris, D., Guerci, A., Ohman, E.M., Barbash, G.I., Betriu, A., Sadowski, Z., Topol, E.J., Califf, R.M. JAMA (1996)
- Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Goldhaber, S.Z., Haire, W.D., Feldstein, M.L., Miller, M., Toltzis, R., Smith, J.L., Taveira da Silva, A.M., Come, P.C., Lee, R.T., Parker, J.A. Lancet (1993)
- Glucocorticoid-modulated gene expression of tissue- and urinary-type plasminogen activator and plasminogen activator inhibitor 1 and 2. Medcalf, R.L., Van den Berg, E., Schleuning, W.D. J. Cell Biol. (1988)