Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

SureCN289034 (3S,8S,9S,10R,13S,14S,17S)- 17-[(2R)-2...

Synonyms: HMDB06283, LMST01010211, DB04704, AC1L99T7, 516-72-3, ...

Jefcoate, C.R., Zhao, D. et al., Kapke, G. et al., Tuckey, R.C. et al., Hochberg, R.B. et al.

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High impact information on 20alpha-Hydroxycholesterol

Fragments formed by the side chain cleavage of a 20-aryl analog of 20alpha-hydroxycholesterol by adrenal mitochondria [1].
Arsenite produced parallel increases in StAR protein expression and cholesterol metabolism, but not for P450scc-mediated metabolism of 20alpha-hydroxycholesterol [2].
Similar results were observed when 20alpha-hydroxycholesterol was used as substrate rather than endogenous cholesterol [3].
Immunochemical evidence for the involvement of adrenal ferredoxin in the side-chain cleavage of 20alpha-hydroxycholesterol [4].

Associations of 20alpha-Hydroxycholesterol with other chemical compounds

With rat adrenal mitochondria cholest-5-ene-3beta, 20alpha-diol (20alpha-hydroxycholesterol) invariably induced a smaller inverse type I response and, under conditions where cytochrome P-450scc was nearly free of cholesterol, even produced a small type I response [5].

References

Fragments formed by the side chain cleavage of a 20-aryl analog of 20alpha-hydroxycholesterol by adrenal mitochondria. Hochberg, R.B., McDonald, P.D., Feldman, M., Lieberman, S. J. Biol. Chem. (1976) [Pubmed]
Novel signaling stimulated by arsenite increases cholesterol metabolism through increases in unphosphorylated steroidogenic acute regulatory (StAR) protein. Zhao, D., Xue, H., Artemenko, I., Jefcoate, C. Mol. Cell. Endocrinol. (2005) [Pubmed]
Electron transfer to cytochrome P-450scc limits cholesterol-side-chain-cleavage activity in the human placenta. Tuckey, R.C., Woods, S.T., Tajbakhsh, M. Eur. J. Biochem. (1997) [Pubmed]
Immunochemical evidence for the involvement of adrenal ferredoxin in the side-chain cleavage of 20alpha-hydroxycholesterol. Kapke, G., Baron, J. Biochem. Biophys. Res. Commun. (1976) [Pubmed]
Cytochrome P-450 of adrenal mitochondria. Spin states as detected by difference spectroscopy. Jefcoate, C.R. J. Biol. Chem. (1975) [Pubmed]

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