The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cyp11a1  -  cytochrome P450, family 11, subfamily a,...

Mus musculus

Synonyms: CYPXIA1, Cholesterol desmolase, Cholesterol side-chain cleavage enzyme, mitochondrial, Cyp11a, Cypxia1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cyp11a1


High impact information on Cyp11a1


Biological context of Cyp11a1


Anatomical context of Cyp11a1


Associations of Cyp11a1 with chemical compounds


Physical interactions of Cyp11a1


Co-localisations of Cyp11a1

  • P450scc mRNA colocalized in all sites where StAR mRNA was found, and in bovine liver [24].

Regulatory relationships of Cyp11a1


Other interactions of Cyp11a1


Analytical, diagnostic and therapeutic context of Cyp11a1


  1. Endogenous estrogens inhibit mouse fetal Leydig cell development via estrogen receptor alpha. Delbès, G., Levacher, C., Duquenne, C., Racine, C., Pakarinen, P., Habert, R. Endocrinology (2005) [Pubmed]
  2. Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Mellon, S.H., Deschepper, C.F. Brain Res. (1993) [Pubmed]
  3. Steroidogenic acute regulatory protein mRNA expression in adrenal tumours. Zenkert, S., Schubert, B., Fassnacht, M., Beuschlein, F., Allolio, B., Reincke, M. Eur. J. Endocrinol. (2000) [Pubmed]
  4. Characterization of adrenal autoantigens recognized by sera from patients with autoimmune polyglandular syndrome (APS) type I. Uibo, R., Perheentupa, J., Ovod, V., Krohn, K.J. J. Autoimmun. (1994) [Pubmed]
  5. Modified expression of steroid 5 alpha-reductase as well as aromatase, but not cholesterol side-chain cleavage enzyme, in the reproductive system of male mice during (Taenia crassiceps) cysticercosis. Morales-Montor, J., Rodríguez-Dorantes, M., Cerbón, M.A. Parasitol. Res. (1999) [Pubmed]
  6. Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: effects on steroidogenesis and oncogenesis. Song, X., Sui, A., Garen, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  7. Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Caron, K.M., Soo, S.C., Wetsel, W.C., Stocco, D.M., Clark, B.J., Parker, K.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13. Sugawara, T., Holt, J.A., Driscoll, D., Strauss, J.F., Lin, D., Miller, W.L., Patterson, D., Clancy, K.P., Hart, I.M., Clark, B.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. Mellon, S.H., Vaisse, C. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. Participation of mitogen-activated protein kinase in luteinizing hormone-induced differential regulation of steroidogenesis and steroidogenic gene expression in mural and cumulus granulosa cells of mouse preovulatory follicles. Su, Y.Q., Nyegaard, M., Overgaard, M.T., Qiao, J., Giudice, L.C. Biol. Reprod. (2006) [Pubmed]
  11. Function of Cyp11a1 in animal models. Hu, M.C., Hsu, H.J., Guo, I.C., Chung, B.C. Mol. Cell. Endocrinol. (2004) [Pubmed]
  12. Cholesterol side-chain cleavage cytochrome P450 gene expression in the primitive gut of the mouse embryo does not require steroidogenic factor 1. Keeney, D.S., Ikeda, Y., Waterman, M.R., Parker, K.L. Mol. Endocrinol. (1995) [Pubmed]
  13. Steroidogenic factor 1 (SF-1) and SP1 are required for regulation of bovine CYP11A gene expression in bovine luteal cells and adrenal Y1 cells. Liu, Z., Simpson, E.R. Mol. Endocrinol. (1997) [Pubmed]
  14. Steroid deficiency syndromes in mice with targeted disruption of Cyp11a1. Hu, M.C., Hsu, N.C., El Hadj, N.B., Pai, C.I., Chu, H.P., Wang, C.K., Chung, B.C. Mol. Endocrinol. (2002) [Pubmed]
  15. Identification of a novel population of adrenal-like cells in the mammalian testis. Val, P., Jeays-Ward, K., Swain, A. Dev. Biol. (2006) [Pubmed]
  16. Transcription of cholesterol side-chain cleavage cytochrome P450 in the placenta: activating protein-2 assumes the role of steroidogenic factor-1 by binding to an overlapping promoter element. Ben-Zimra, M., Koler, M., Orly, J. Mol. Endocrinol. (2002) [Pubmed]
  17. Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function. Jeyasuria, P., Ikeda, Y., Jamin, S.P., Zhao, L., De Rooij, D.G., Themmen, A.P., Behringer, R.R., Parker, K.L. Mol. Endocrinol. (2004) [Pubmed]
  18. Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein. Hales, K.H., Diemer, T., Ginde, S., Shankar, B.K., Roberts, M., Bosmann, H.B., Hales, D.B. Endocrinology (2000) [Pubmed]
  19. Characterization of the rat Star gene that encodes the predominant 3.5-kilobase pair mRNA. ACTH stimulation of adrenal steroids in vivo precedes elevation of Star mRNA and protein. Ariyoshi, N., Kim, Y.C., Artemenko, I., Bhattacharyya, K.K., Jefcoate, C.R. J. Biol. Chem. (1998) [Pubmed]
  20. Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3beta-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. Cherradi, N., Rossier, M.F., Vallotton, M.B., Timberg, R., Friedberg, I., Orly, J., Wang, X.J., Stocco, D.M., Capponi, A.M. J. Biol. Chem. (1997) [Pubmed]
  21. Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor. Bastida, C.M., Tejada, F., Cremades, A., Peñafiel, R. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  22. Presence of identical mitochondrial proteins in unstimulated constitutive steroid-producing R2C rat Leydig tumor and stimulated nonconstitutive steroid-producing MA-10 mouse Leydig tumor cells. Stocco, D.M., Chen, W. Endocrinology (1991) [Pubmed]
  23. NH2 terminus of PTB-associated splicing factor binds to the porcine P450scc IGF-I response element. Urban, R.J., Bodenburg, Y.H., Wood, T.G. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  24. Steroidogenic acute regulatory protein in bovine corpora lutea. Pescador, N., Soumano, K., Stocco, D.M., Price, C.A., Murphy, B.D. Biol. Reprod. (1996) [Pubmed]
  25. The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain. King, S.R., Ginsberg, S.D., Ishii, T., Smith, R.G., Parker, K.L., Lamb, D.J. Endocrinology (2004) [Pubmed]
  26. Transcriptional Regulation of the Cholesterol Side Chain Cleavage Cytochrome P450 Gene (CYP11A1) Revisited: Binding of GATA, Cyclic Adenosine 3',5'-Monophosphate Response Element-Binding Protein and Activating Protein (AP)-1 Proteins to a Distal Novel Cluster of cis-Regulatory Elements Potentiates AP-2 and Steroidogenic Factor-1-Dependent Gene Expression in the Rodent Placenta and Ovary. Sher, N., Yivgi-Ohana, N., Orly, J. Mol. Endocrinol. (2007) [Pubmed]
  27. Further characterization of the inhibitory effect of monensin on adrenal steroidogenesis. Cheng, B., Horst, I.A., Kowal, J. J. Steroid Biochem. (1990) [Pubmed]
  28. Pubertal and adult Leydig cell function in Mullerian inhibiting substance-deficient mice. Wu, X., Arumugam, R., Baker, S.P., Lee, M.M. Endocrinology (2005) [Pubmed]
  29. Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function. Manna, P.R., Kero, J., Tena-Sempere, M., Pakarinen, P., Stocco, D.M., Huhtaniemi, I.T. Endocrinology (2001) [Pubmed]
  30. Steroidogenic factor-1 controls the aldose reductase akr1b7 gene promoter in transgenic mice through an atypical binding site. Martinez, A., Val, P., Sahut-Barnola, I., Aigueperse, C., Veyssière, G., Lefrançois-Martinez, A.M. Endocrinology (2003) [Pubmed]
  31. Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression. Liu, Z., Simpson, E.R. Mol. Cell. Endocrinol. (1999) [Pubmed]
  32. Ontogeny of expression of the genes for steroidogenic enzymes P450 side-chain cleavage, 3 beta-hydroxysteroid dehydrogenase, P450 17 alpha-hydroxylase/C17-20 lyase, and P450 aromatase in fetal mouse gonads. Greco, T.L., Payne, A.H. Endocrinology (1994) [Pubmed]
  33. In vivo effects of adrenocorticotropin on hamster adrenal steroidogenic enzymes. LeHoux, J.G., Mason, J.I., Ducharme, L. Endocrinology (1992) [Pubmed]
  34. Effects of 3,3',4,4',5-pentachlorobiphenyl, a coplanar polychlorinated biphenyl congener, on cultured neonatal mouse testis. Fukuzawa, N.H., Ohsako, S., Nagano, R., Sakaue, M., Baba, T., Aoki, Y., Tohyama, C. Toxicology in vitro : an international journal published in association with BIBRA. (2003) [Pubmed]
WikiGenes - Universities