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Chemical Compound Review:

DL-THA (2S,3S)-2-amino-3-hydroxy- butanedioic acid

Synonyms: Tocris-0183, AG-F-52411, CHEBI:10696, H2775_SIGMA, CCG-204654, ...

Wada, M. et al., Balcar, V.J. et al., Abe, K. et al., Wada, M. et al.

Wada, Nakamori, Takagi,

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Disease relevance of C11511

Purification and characterization of a novel enzyme, L-threo-3-hydroxyaspartate dehydratase, from Pseudomonas sp. T62 [1].

High impact information on C11511

L-trans-Pyrrolidine-2,4-dicarboxylate (L-t-PDC) and L-threo-3- hydroxyaspartate (L-t-3OHA), compounds known to interact strongly with the Na(+)-dependent high affinity uptake of excitatory amino acids in central nervous tissue, were tested as potential inhibitors of binding to glutamate receptors and transport sites in frozen sections of rat brain [2].
In addition, the enzyme showed a dehydratase activity toward l-threo-3-hydroxyaspartate, similar to the mammalian serine racemase that produces pyruvate from d- and l-serine [3].
The SRY1 gene product exhibited dehydratase activity specific for L-threo-3-hydroxyaspartate (K(m)=3.9 mM, V(max)=110 micromol min(-1) (mg protein)(-1)) but not for D-threo- or DL-erythro-3-hydroxyaspartate [4].
Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity [4].

Chemical compound and disease context of C11511

The NH(2)-terminal amino acid sequence of L-threo-3-hydroxyaspartate dehydratase from Pseudomonas sp. T62 showed significant similarity to that of the SRY1 gene product of Saccharomyces cerevisiae (serine racemase in yeast) [4].

References

Purification and characterization of a novel enzyme, L-threo-3-hydroxyaspartate dehydratase, from Pseudomonas sp. T62. Wada, M., Matsumoto, T., Nakamori, S., Sakamoto, M., Kataoka, M., Liu, J.Q., Itoh, N., Yamada, H., Shimizu, S. FEMS Microbiol. Lett. (1999) [Pubmed]
Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and [3H]kainate studied by autoradiography in rat forebrain. Balcar, V.J., Li, Y., Killinger, S. Neurochem. Int. (1995) [Pubmed]
Cloning and Expression of the Pyridoxal 5'-Phosphate-Dependent Aspartate Racemase Gene from the Bivalve Mollusk Scapharca broughtonii and Characterization of the Recombinant Enzyme. Abe, K., Takahashi, S., Muroki, Y., Kera, Y., Yamada, R.H. J. Biochem. (2006) [Pubmed]
Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity. Wada, M., Nakamori, S., Takagi, H. FEMS Microbiol. Lett. (2003) [Pubmed]

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