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Chemical Compound Review:

AC1L9ES8 [(3R,4S,6R)-4-dimethylamino- 3-hydroxy-6...

Synonyms:

Rodríguez, E. et al., Salah-Bey, K. et al., Doumith, M. et al.

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Disease relevance of C11911

In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea [1].
In a further set of experiments, the putative desosaminyltransferase of Sac. erythraea, EryCIII, was expressed in the picromycin producer Streptomyces sp. 20032, which also synthesises dTDP-D-desosamine [2].
The production of erythromycin A by Saccharopolyspora erythraea requires the synthesis of dTDP-D-desosamine and dTDP-L-mycarose, which serve as substrates for the transfer of the two sugar residues onto the macrolactone ring [3].
In vivo reconstitution of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea was achieved by expression of the genes in Escherichia coli [1].

High impact information on C11911

LC/MS/MS analysis of the dTDP-sugar intermediates produced by operons containing different sets of genes showed that production of dTDP-D-desosamine from dtdp-4-keto-6-deoxy-D-glucose requires only four biosynthetic steps, catalysed by MegCIV, MegCV, MegDII and MegDIII, and that MegCII is not involved [1].

References

In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea. Rodríguez, E., Peirú, S., Carney, J.R., Gramajo, H. Microbiology (Reading, Engl.) (2006) [Pubmed]
Analysis of genes involved in 6-deoxyhexose biosynthesis and transfer in Saccharopolyspora erythraea. Doumith, M., Weingarten, P., Wehmeier, U.F., Salah-Bey, K., Benhamou, B., Capdevila, C., Michel, J.M., Piepersberg, W., Raynal, M.C. Mol. Gen. Genet. (2000) [Pubmed]
Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea. Salah-Bey, K., Doumith, M., Michel, J.M., Haydock, S., Cortés, J., Leadlay, P.F., Raynal, M.C. Mol. Gen. Genet. (1998) [Pubmed]

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