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Chemical Compound Review

CHEMBL62136     N-[4-(1,1,1,3,3,3-hexafluoro- 2-hydroxy...

Synonyms: CHEBI:39976, T2320_SIGMA, ML125, AC1L9LDO, KB-75263, ...
 
 
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Disease relevance of T-0901317

  • Therefore, LXRbeta may represent a novel therapeutic target for the treatment of dyslipidemia and atherosclerosis.Here, we report the X-ray crystal structure of the LXRbeta ligand-binding domain in complex with a synthetic agonist, T-0901317 [1].
 

High impact information on T-0901317

 

Anatomical context of T-0901317

 

Gene context of T-0901317

  • T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice [3].

References

  1. Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist. Hoerer, S., Schmid, A., Heckel, A., Budzinski, R.M., Nar, H. J. Mol. Biol. (2003) [Pubmed]
  2. Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation. Svensson, S., Ostberg, T., Jacobsson, M., Norström, C., Stefansson, K., Hallén, D., Johansson, I.C., Zachrisson, K., Ogg, D., Jendeberg, L. EMBO J. (2003) [Pubmed]
  3. T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice. Terasaka, N., Hiroshima, A., Koieyama, T., Ubukata, N., Morikawa, Y., Nakai, D., Inaba, T. FEBS Lett. (2003) [Pubmed]
 
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