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Chemical Compound Review:

MOLI001322 3-(1-hydroxy-2-methylamino- propyl)phenol

Synonyms: AC1L9P66, [11C]mHED, [11C]HED, [11C]meta-Hydroxyephedrine, (1R, 2S)-[11C]meta-Hydroxyephedrine, ...

Schwaiger, M. et al., Schmid, H. et al., Rosenspire, K.C. et al., Hutchins, G.D. et al., Mazzadi, A.N. et al.

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High impact information on MOLI001322

In ND rats, no difference in [11C]HED retention or norepinephrine content was detected in the proximal versus distal myocardium [1].
Images of the retention of [11C]HED taken from 50 to 60 min postinjection were used to differentiate sympathetically innervated and denervated regions of the left ventricle [2].

Anatomical context of MOLI001322

After 6 months, compared with ND rats, myocardial [11C]HED retention had declined in the proximal segments of STZ-D rats by only 9% (NS) compared with a 33% decrease in the distal myocardium (P < 0.05) [1].

Analytical, diagnostic and therapeutic context of MOLI001322

Positron emission tomography in combination with the newly introduced catecholamine analogue [11C]hydroxyephedrine ([11C]HED) enables the noninvasive delineation of sympathetic nerve terminals of the heart [3].
Quantitative evaluation of [11C]HED retention revealed a 70% reduction in group I and 59% reduction in group II patients (P less than 0.001) [3].
Metabolic studies in guinea pigs show less than 5% metabolites in heart tissue 30 min after intravenous injection suggesting that [11C]meta-hydroxyephedrine is suitable for kinetic modeling [4].
Sectorial values of perfusion (H2O%), absolute (HEDRet) and relative retention (HED%Ret) of [11C]HED, and the ratio of HED%Ret to H2O% (HED%Ret/H2O%) were calculated [5].

References

Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: implications for cardiac sympathetic dysinnervation complicating diabetes. Schmid, H., Forman, L.A., Cao, X., Sherman, P.S., Stevens, M.J. Diabetes (1999) [Pubmed]
PET imaging of oxidative metabolism abnormalities in sympathetically denervated canine myocardium. Hutchins, G.D., Chen, T., Carlson, K.A., Fain, R.L., Winkle, W., Vavrek, T., Mock, B.H., Zipes, D.P. J. Nucl. Med. (1999) [Pubmed]
Evidence for regional catecholamine uptake and storage sites in the transplanted human heart by positron emission tomography. Schwaiger, M., Hutchins, G.D., Kalff, V., Rosenspire, K., Haka, M.S., Mallette, S., Deeb, G.M., Abrams, G.D., Wieland, D. J. Clin. Invest. (1991) [Pubmed]
Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: a false transmitter agent for heart neuronal imaging. Rosenspire, K.C., Haka, M.S., Van Dort, M.E., Jewett, D.M., Gildersleeve, D.L., Schwaiger, M., Wieland, D.M. J. Nucl. Med. (1990) [Pubmed]
Cardiac retention of [11C]HED in genotyped long QT patients: a potential amplifier role for severity of the disease. Mazzadi, A.N., André-Fouët, X., Duisit, J., Gebuhrer, V., Costes, N., Chevalier, P., Rodriguez, C., Schott, J.J., Le Marec, H., Guicheney, P., Le Bars, D., Janier, M. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]

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