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Chemical Compound Review:

Zolafren

Synonyms: Olansek, Olzapin, Symbyax, Zalasta, Zypadhera, ...

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Psychiatry related information on Zyprexa

The weight management program was effective in terms of weight reduction in patients with schizophrenia or schizoaffective disorder taking olanzapine and was also found to be safe in terms of psychiatric symptoms, vital signs, and laboratory data [1].

Chemical compound and disease context of Zyprexa

More weight gain occurred with olanzapine than with risperidone: the increase in weight at 4 months relative to baseline weight was 17.3% (95% CI=14.2%-20.5%) with olanzapine and 11.3% (95% CI=8.4%-14.3%) with risperidone [2].

Associations of Zyprexa with other chemical compounds

The weight, body mass index, waist circumference, and waist-to-hip ratio levels increased less in the olanzapine plus metformin group relative to the olanzapine plus placebo group during the 12-week follow-up period [3].

References

Weight management program for treatment-emergent weight gain in olanzapine-treated patients with schizophrenia or schizoaffective disorder: A 12-week randomized controlled clinical trial. Kwon, J.S., Choi, J.S., Bahk, W.M., Yoon Kim, C., Hyung Kim, C., Chul Shin, Y., Park, B.J., Geun Oh, C. J. Clin. Psychiatry (2006) [Pubmed]
Randomized comparison of olanzapine versus risperidone for the treatment of first-episode schizophrenia: 4-month outcomes. Robinson, D.G., Woerner, M.G., Napolitano, B., Patel, R.C., Sevy, S.M., Gunduz-Bruce, H., Soto-Perello, J.M., Mendelowitz, A., Khadivi, A., Miller, R., McCormack, J., Lorell, B.S., Lesser, M.L., Schooler, N.R., Kane, J.M. Am. J. Psychiatry (2006) [Pubmed]
Metformin addition attenuates olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: a double-blind, placebo-controlled study. Wu, R.R., Zhao, J.P., Guo, X.F., He, Y.Q., Fang, M.S., Guo, W.B., Chen, J.D., Li, L.H. Am. J. Psychiatry (2008) [Pubmed]

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