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Chemical Compound Review

Z-Phe-phe-gly     2-[[(2S)-3-phenyl-2-[[(2R)-3- phenyl-2...

Synonyms: AC1LATT3, SureCN10521480, AR-1K3241, AC1Q75X6, AC1Q75X7, ...
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Disease relevance of Carbobenzoxy-D-Phe-L-Phe-Gly


High impact information on Carbobenzoxy-D-Phe-L-Phe-Gly

  • In addition, the oligopeptide Z-D-Phe-L-Phe-Gly, also homologous to F and SP, inhibits MV fusion with target cells [3].
  • As revealed by our previous studies, proteolytic cleavage of the MV F protein precursor into its F1 and F2 subunits, but not of F/H-mediated cellular fusion, was found to be required, since fusion-inhibitory peptides such as Z-D-Phe-L-Phe-Gly (Z-fFG) did not interfere with the induction of proliferative inhibition [4].
  • Calorimetric titrations conducted over a range of temperatures permitted characterization of the thermodynamics of the interaction of Z-D-Phe-L-Phe-Gly with model DOPC lipid membranes [5].
  • The uptake of [125I]iodoinsulin by adipocytes is inhibited by carbobenzoxy-D-Phe-L-Phe-Gly [6].
  • When anti-MV serum or carbobenzoxy-D-Phe-L-Phe-Gly, a synthetic oligopeptide known to inhibit MV-induced fusion, was added 24 hr after infection, the inhibition of T cell proliferation was reversed in a dose-dependent manner [7].

Analytical, diagnostic and therapeutic context of Carbobenzoxy-D-Phe-L-Phe-Gly

  • The binding of the fusion-inhibiting peptide Z-D-Phe-L-Phe-Gly to unilamellar lipid vesicles of dioleoylphosphatidylcholine (DOPC) was investigated by isothermal titration calorimetry (ITC) [5].


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