Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEMBL61006 2-amino-1-phenyl-propan-1-ol

Synonyms: SureCN98589, AG-K-92663, NINDS_000795, NSC-120735, AC1L1IYB, ...

Morien, A. et al., McLeod, R.L. et al.

McLeod, Rizzo, West, Aslanian, McCormick, Bryant, Hsieh, Korfmacher, Mingo, Varty, Williams, Shih, Egan, Hey,

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High impact information on Norephedrine

Unlike the H3/H1 combination that did not affect blood pressure (BP), PPA (1 mg/kg i.v.) significantly increased BP compared with control animals by a maximum of 31 mm Hg [1].
Activation of alpha-1 adrenoceptors, via systemic injection of agonists such as cirazoline and phenylpropanolamine (PPA), reliably suppresses food intake in rats [2].

Anatomical context of Norephedrine

These effects are thought to result from stimulation of central alpha 1-adrenoceptors within the rat paraventricular hypothalamic nucleus (PVN), based on studies in which direct injections of cirazoline, methoxamine, phenylephrine and PPA into PVN suppress food intake [2].

References

Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687). McLeod, R.L., Rizzo, C.A., West, R.E., Aslanian, R., McCormick, K., Bryant, M., Hsieh, Y., Korfmacher, W., Mingo, G.G., Varty, L., Williams, S.M., Shih, N.Y., Egan, R.W., Hey, J.A. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
Effects on food and water intake of the alpha 1-adrenoceptor agonists amidephrine and SK&F-89748. Morien, A., McMahon, L., Wellman, P.J. Life Sci. (1993) [Pubmed]

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