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Chemical Compound Review:

CHEMBL21157 4-(diaminomethylideneamino) butanoic acid

Synonyms: AG-K-66121, CHEBI:15728, G6503_SIGMA, HMDB03464, CCG-36583, ...

O'malley, L.P. et al., De Deyn, P.P. et al., Al Banchaabouchi, M. et al., Carmona, P. et al., Vanderbilt, A.S. et al.

Carmona, Molina, Rodríguez-Casado, O'malley, Collins, White,

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Disease relevance of gamma-guanidinobutyrate

Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida [1].

High impact information on gamma-guanidinobutyrate

Even more pronounced regional differences were found for gamma-guanidinobutyric acid with the lowest concentration in the caudate nucleus (0.6 +/- 0.3 nmol/g tissue) and highest in substantia nigra, pallidum and cerebellar dentate nucleus (8.3 +/- 2.8 nmol/g tissue) [2].
The complex between adenosine triphosphate (ATP) and 4-guanidinobutyric acid (GBA) has been studied by infrared spectroscopy dry and hydrated (60% relative humidity) [3].
Using PHMB model compounds (1,6-diaminohexane; 1,6-diguanidinohexane; 1,6-di(cyanoguanidino)hexane; 4-guanidinobutyric acid), we have determined the biodegradation characteristics of each end-group in several strains of bacteria isolated for their ability to utilise PHMB as a sole source of nitrogen [4].

Gene context of gamma-guanidinobutyrate

In brain, GAA and gamma-guanidinobutyric acid (GBA) levels were always higher in NX mice with a tendency to respectively increase or decrease over time in NX as well as sham-operated mice [5].

References

Intermediates and enzymes between alpha-ketoarginine and gamma-guanidinobutyrate in the L-arginine catabolic pathway of Pseudomonas putida. Vanderbilt, A.S., Gaby, N.S., Rodwell, V.W. J. Biol. Chem. (1975) [Pubmed]
Guanidino compound levels in brain regions of non-dialyzed uremic patients. De Deyn, P.P., Marescau, B., D'Hooge, R., Possemiers, I., Nagler, J., Mahler, C. Neurochem. Int. (1995) [Pubmed]
On the role of arginine-glutamic acid ion pair in the ATP hydrolysis. Carmona, P., Molina, M., Rodríguez-Casado, A. Biophys. Chem. (2006) [Pubmed]
Biodegradability of end-groups of the biocide polyhexamethylene biguanide (PHMB) assessed using model compounds. O'malley, L.P., Collins, A.N., White, G.F. J. Ind. Microbiol. Biotechnol. (2006) [Pubmed]
Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice. Al Banchaabouchi, M., Marescau, B., Van Marck, E., D'hooge, R., De Deyn, P.P. Metab. Clin. Exp. (2001) [Pubmed]

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