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Chemical Compound Review

HMDA     hexane-1,6-diamine

Synonyms: diaminohexane, HEX-NH2, CHEMBL303004, HSDB 189, NSC-9257, ...
 
 
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Disease relevance of HSDB 189

 

Psychiatry related information on HSDB 189

 

High impact information on HSDB 189

 

Biological context of HSDB 189

 

Anatomical context of HSDB 189

  • A series of these microcapsules with poly(hexamethyleneterephthalamide) membranes was prepared by interfacial polymerization with an 8-fold variation of hexamethylenediamine concentration in the aqueous emulsion phase [14].
  • The acute neurotoxicity of a homologous series of diamines (ethylenediamine to 1,6-diaminohexane) was tested by injection into the lateral ventricle of conscious rats, documented as changes in behavior and electroencephalogram (EEG) [15].
 

Associations of HSDB 189 with other chemical compounds

 

Gene context of HSDB 189

  • 3. The results indicate that the cell differentiating agent hexamethylene bisacetamide is converted into 1,6-diaminohexane, and its metabolism therefore involves diamine oxidase [17].
  • Incubation of serum serpin (alpha-1-antitrypsin) with 5 mM 1,6-diaminohexane causes significant loss of heterozygotic inhibitor activity [20].
  • However, both TEM and SEM data indicated structural differences when lower concentrations of hexamethylenediamine were used, there being a more uniform formation to give a distinct outer membrane layer (18-45 nm) visible on cross-section and appearing as a smooth outer surface [21].
  • Hexamethylendiamine (HMDA; CAS No. 124-09-4; 6055-52-3 for the dihydrochloride salt) is moderately toxic following acute doses/exposures with oral lethal doses in rats ranging from 750 to 1500 mg/kg [2].
  • The urinary level of HDA, in samples collected immediately after the end of the exposures, was on average 0.02 mmol/mol creatinine (range 0.01-0.03 mmol/mol creatinine) [22].
 

Analytical, diagnostic and therapeutic context of HSDB 189

References

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