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Chemical Compound Review

AGN-PC-00IYUR     4-[[10,13-dimethyl-17-(6- methylheptan-2...

Synonyms: SureCN463416, AG-D-97820, ACMC-209d5a, CTK8F8629, NSC628321, ...
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Disease relevance of NSC628321

  • For the CBP pancreatic cancer line, CHS treatment increased tumor immunogenicity significantly, as demonstrated by diminished tumor growth rate and by increased duration of survival after challenge [1].

High impact information on NSC628321

  • Tumor cells were incubated in CHS to rigidify cell membranes, and they were irradiated and injected i.p. into syngeneic hamsters [1].
  • With the LSP-1 pancreatic tumor, immunization with CHS-treated cells showed no enhancement of immunogenicity [1].
  • The NCI-H720 BN/GRP receptor was purified 86,000-fold after extraction with CHAPS/CHS and purification using both affinity resins [2].
  • Thymic lymphocytes, instead, do not exhibit changes in Thy expression upon CHS treatment although cell membranes become rigidified [3].

Analytical, diagnostic and therapeutic context of NSC628321


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