Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AGN-PC-00IYUR 4-[[10,13-dimethyl-17-(6- methylheptan-2...

Synonyms: SureCN463416, AG-D-97820, ACMC-209d5a, CTK8F8629, NSC628321, ...

Skornick, Y. et al., Krueger, G.R. et al., Staley, J. et al.

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Disease relevance of NSC628321

For the CBP pancreatic cancer line, CHS treatment increased tumor immunogenicity significantly, as demonstrated by diminished tumor growth rate and by increased duration of survival after challenge [1].

High impact information on NSC628321

Tumor cells were incubated in CHS to rigidify cell membranes, and they were irradiated and injected i.p. into syngeneic hamsters [1].
With the LSP-1 pancreatic tumor, immunization with CHS-treated cells showed no enhancement of immunogenicity [1].
The NCI-H720 BN/GRP receptor was purified 86,000-fold after extraction with CHAPS/CHS and purification using both affinity resins [2].
Thymic lymphocytes, instead, do not exhibit changes in Thy expression upon CHS treatment although cell membranes become rigidified [3].

Analytical, diagnostic and therapeutic context of NSC628321

Use of CHS-treated cells or shed antigeneic material could be of potential value as a method of active immunotherapy [1].

References

Active immunization of hamsters against pancreatic carcinoma with lipid-treated cells or their shed antigens. Skornick, Y., Kurman, C.C., Sindelar, W.F. Cancer Res. (1984) [Pubmed]
Solubilization and purification of bombesin/gastrin releasing peptide receptors from human cell lines. Staley, J., Coy, D.H., Jensen, R.T., Moody, T.W. J. Mol. Neurosci. (1993) [Pubmed]
Cell membrane lipid fluidity and receptor expression in Moloney- and Friend virus-transformed cells. Krueger, G.R., Stolzenburg, T., Muller, C. In Vivo (1987) [Pubmed]

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