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Chemical Compound Review

NN-DNJ     (2R,3R,4R,5S)-2- (hydroxymethyl)-1-nonyl...

Synonyms: N-Nonyl-DNJ, CHEMBL408500, AG-H-25955, SureCN2268575, CHEBI:49775, ...
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Disease relevance of NN-DNJ


High impact information on NN-DNJ

  • We propose that NN-DNJ chaperones beta-Glu folding at neutral pH, thus allowing the stabilized enzyme to transit from the endoplasmic reticulum to the Golgi, enabling proper trafficking to the lysosome [2].

Anatomical context of NN-DNJ

  • We report herein that the addition of subinhibitory concentrations (10 microM) of N-(n-nonyl)deoxynojirimycin (NN-DNJ) to a fibroblast culture medium for 9 days leads to a 2-fold increase in the activity of N370S beta-Glu, the most common mutation causing Gaucher disease [2].


  1. Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking. Block, T.M., Lu, X., Mehta, A.S., Blumberg, B.S., Tennant, B., Ebling, M., Korba, B., Lansky, D.M., Jacob, G.S., Dwek, R.A. Nat. Med. (1998) [Pubmed]
  2. Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease. Sawkar, A.R., Cheng, W.C., Beutler, E., Wong, C.H., Balch, W.E., Kelly, J.W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Antiviral effects of an iminosugar derivative on flavivirus infections. Wu, S.F., Lee, C.J., Liao, C.L., Dwek, R.A., Zitzmann, N., Lin, Y.L. J. Virol. (2002) [Pubmed]
  4. A dengue Fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. Schul, W., Liu, W., Xu, H.Y., Flamand, M., Vasudevan, S.G. J. Infect. Dis. (2007) [Pubmed]
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