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Chemical Compound Review:

SureCN762579 1-[5-(hydroxymethyl)oxolan-2- yl]-5-methyl...

Synonyms: AG-J-05109, CCG-24684, CHEBI:129882, NSC-617596, KB-09251, ...

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Disease relevance of NSC617596

Some 3'-deoxythymidine analogues having anti-human immunodeficiency virus activity were inactive against herpesviruses [1].
Aryl phosphate derivatives of 3'-deoxythymidine (3dT), albeit more active than 3dT in thymidine kinase (TK)-deficient cells, are not potent anti-human immunodeficiency virus (HIV) agents and are capable of inhibiting HIV replication only at micromolar concentrations [2].

High impact information on NSC617596

Antiretroviral combinations (HAART) that contained NRTIs (stavudine (2', 3'-didehydro-2', 3'-deoxythymidine or d4T)/lamivudine/indinavir; or zidovudine (3' azido-3'-deoxythymidine or AZT)/lamivudine/indinavir; 35 days) were administered to simulate AIDS therapy [3].
We now demonstrate that the liponucleotides of dideoxycytidine, 3'-deoxythymidine and 3'-azido-3'-deoxythymidine (AZT, Zidovudine) can substitute to varying extents for CDP-DG in the biosynthesis of phosphatidylinositol, phosphatidylglycerol or diphosphatidylglycerol by rat liver subcellular fractions [4].

Analytical, diagnostic and therapeutic context of NSC617596

3'-azido-2', 3'-deoxythymidine (AZT) concentrations in spiked human plasma were determined by means of reversed-phase high performance liquid chromatography (RP-HPLC) [5].

References

Structure-activity relationship of the affinity of 5-substituted uracil nucleoside analogues for varicella-zoster virus thymidine kinase and their activity against varicella-zoster virus. Ashida, N., Watanabe, Y., Miura, S., Kano, F., Sakata, S., Yamaguchi, T., Suzutani, T., Machida, H. Antiviral Res. (1997) [Pubmed]
Aryl phosphate derivatives of 3'-deoxythymidine are not potent anti-human immunodeficiency virus agents. Vig, R., Venkatachalam, T.K., Jan, S.T., Uckun, F.M. Antivir. Chem. Chemother. (1998) [Pubmed]
Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS. Lewis, W., Haase, C.P., Miller, Y.K., Ferguson, B., Stuart, T., Ludaway, T., McNaught, J., Russ, R., Steltzer, J., Santoianni, R., Long, R., Fiermonte, G., Palmieri, F. Lab. Invest. (2005) [Pubmed]
Cytidine diphosphate diglyceride analogs of antiretroviral dideoxynucleosides: evidence for release of dideoxynucleoside-monophosphates by phospholipid biosynthetic enzymes in rat liver subcellular fractions. van Wijk, G.M., Hostetler, K.Y., Schlame, M., van den Bosch, H. Biochim. Biophys. Acta (1991) [Pubmed]
HPLC-monitoring of AZT in HIV-infected patient's plasma: a critical study. Borvák, J., Kasanická, J., Mayer, V. Acta Virol. (1992) [Pubmed]

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