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Chemical Compound Review:

AC1NQX0E (3Z,5Z)-6-hydroxy-2-oxo-6- phenyl-hexa-3,5...

Synonyms: C01273, 2,6-dioxo-6-phenylhexa-3-enoate

Lau, P.C. et al., Hofer, B. et al., Seah, S.Y. et al., Yamada, A. et al., Khan, A.A. et al., et al.

Lau, Garnon, Labbé, Wang,

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Disease relevance of C01273

The ability of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (HOPDA) hydrolase (BphD) of Burkholderia cepacia LB400 to hydrolyze polychlorinated biphenyl (PCB) metabolites was assessed by determining its specificity for monochlorinated HOPDAs [1].
The two HOHD hydrolase genes and the RHA1 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (HPDA) hydrolase gene, bphD, were expressed in Escherichia coli, and their relative enzymatic activities were examined [2].
Location and sequence analysis of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase-encoding gene (bpdF) of the biphenyl/polychlorinated biphenyl degradation pathway in Rhodococcus sp. M5 [3].

High impact information on C01273

The 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (HOPD) hydrolase-encoding gene (bpdF) in the biphenyl (BP)/polychlorinated biphenyl (PCB)-degrading bacterium, Rhodococcus sp. M5 (M5), was found to be located within a 4.5-kb HindIII-BamHI genomic DNA that was 5.4 kb downstream from the bpdC1C2BADE gene cluster [3].
Seven structural genes, encoding biphenyl dioxygenase (bphA1A2A3A4), biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (bphB), biphenyl-2,3-diol-1,2-dioxygenase (bphC) and 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (bphD), have been located [4].
Identification and localization of 3-phenylcatechol dioxygenase and 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase genes of Pseudomonas putida and expression in Escherichia coli [5].
The nucleotide sequence of the flanking region of each bphC revealed a homolog of the 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate (HOPD) hydrolase gene, bphD, just upstream of bphC5 [6].

References

Identification of a serine hydrolase as a key determinant in the microbial degradation of polychlorinated biphenyls. Seah, S.Y., Labbé, G., Nerdinger, S., Johnson, M.R., Snieckus, V., Eltis, L.D. J. Biol. Chem. (2000) [Pubmed]
Two nearly identical aromatic compound hydrolase genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1. Yamada, A., Kishi, H., Sugiyama, K., Hatta, T., Nakamura, K., Masai, E., Fukuda, M. Appl. Environ. Microbiol. (1998) [Pubmed]
Location and sequence analysis of a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase-encoding gene (bpdF) of the biphenyl/polychlorinated biphenyl degradation pathway in Rhodococcus sp. M5. Lau, P.C., Garnon, J., Labbé, D., Wang, Y. Gene (1996) [Pubmed]
Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation. Hofer, B., Eltis, L.D., Dowling, D.N., Timmis, K.N. Gene (1993) [Pubmed]
Identification and localization of 3-phenylcatechol dioxygenase and 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase genes of Pseudomonas putida and expression in Escherichia coli. Khan, A.A., Walia, S.K. Appl. Environ. Microbiol. (1990) [Pubmed]
Diversity of 2,3-dihydroxybiphenyl dioxygenase genes in a strong PCB degrader, Rhodococcus sp. strain RHA1. Sakai, M., Masai, E., Asami, H., Sugiyama, K., Kimbara, K., Fukuda, M. J. Biosci. Bioeng. (2002) [Pubmed]

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