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Chemical Compound Review

SureCN94298     3-phenylbenzene-1,2-diol

Synonyms: CHEBI:16205, CTK0H5951, ZINC00901387, AR-1H9871, DB02923, ...
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Disease relevance of BIPHENYL-23-DIOL

  • The crystal structure of 2,3-dihydroxybiphenyl 1,2-dioxygenase from a PCB-degrading strain of Pseudomonas cepacia has been determined at 1.9 angstrom resolution [1].
  • Analysis of three 2,3-dihydroxybiphenyl 1,2-dioxygenases found in Rhodococcus globerulus P6. Identification of a new family of extradiol dioxygenases [2].
  • 2,3-Dihydroxybiphenyl 1,2-dioxygenase II, encoded by the bphC2 gene, was purified to apparent homogeneity from a recombinant Escherichia coli strain [2].
  • Recent studies demonstrated that 2,3-dihydroxybiphenyl 1,2-dioxygenase from Burkholderia sp. strain LB400 (DHBDLB400; EC cleaves chlorinated 2,3-dihydroxybiphenyls (DHBs) less specifically than unchlorinated DHB and is competitively inhibited by 2',6'-dichloro-2,3-dihydroxybiphenyl (2',6'-diCl DHB) [3].
  • The 2,3-dihydroxybiphenyl dioxygenase from Sphingomonas sp. strain BN6 (BphC1-BN6) differs from most other extradiol dioxygenases by its ability to oxidize 3-chlorocatechol to 3-chloro-2-hydroxymuconic semialdehyde by a distal cleavage mechanism [4].

High impact information on BIPHENYL-23-DIOL


Chemical compound and disease context of BIPHENYL-23-DIOL


Biological context of BIPHENYL-23-DIOL


Associations of BIPHENYL-23-DIOL with other chemical compounds


Gene context of BIPHENYL-23-DIOL


Analytical, diagnostic and therapeutic context of BIPHENYL-23-DIOL


  1. Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad. Han, S., Eltis, L.D., Timmis, K.N., Muchmore, S.W., Bolin, J.T. Science (1995) [Pubmed]
  2. Analysis of three 2,3-dihydroxybiphenyl 1,2-dioxygenases found in Rhodococcus globerulus P6. Identification of a new family of extradiol dioxygenases. Asturias, J.A., Eltis, L.D., Prucha, M., Timmis, K.N. J. Biol. Chem. (1994) [Pubmed]
  3. Characterization of extradiol dioxygenases from a polychlorinated biphenyl-degrading strain that possess higher specificities for chlorinated metabolites. Vaillancourt, F.H., Haro, M.A., Drouin, N.M., Karim, Z., Maaroufi, H., Eltis, L.D. J. Bacteriol. (2003) [Pubmed]
  4. Catalytic properties of the 3-chlorocatechol-oxidizing 2, 3-dihydroxybiphenyl 1,2-dioxygenase from Sphingomonas sp. strain BN6. Riegert, U., Heiss, G., Kuhm, A.E., Müller, C., Contzen, M., Knackmuss, H.J., Stolz, A. J. Bacteriol. (1999) [Pubmed]
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  8. Cloning and nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene from the PCB-degrading strain of Pseudomonas paucimobilis Q1. Taira, K., Hayase, N., Arimura, N., Yamashita, S., Miyazaki, T., Furukawa, K. Biochemistry (1988) [Pubmed]
  9. Crystallization and preliminary crystallographic analysis of a 2,3-dihydroxybiphenyl dioxygenase from Pseudomonas sp. strain KKS102 having polychlorinated biphenyl (PCB)-degrading activity. Sugiyama, K., Narita, H., Yamamoto, T., Senda, T., Kimbara, K., Inokuchi, N., Iwama, M., Irie, M., Fukuda, M., Yano, K. Proteins (1995) [Pubmed]
  10. Molecular cloning of 3-phenylcatechol dioxygenase involved in the catabolic pathway of chlorinated biphenyl from Pseudomonas putida and its expression in Escherichia coli. Khan, A., Tewari, R., Walia, S. Appl. Environ. Microbiol. (1988) [Pubmed]
  11. The catechol 2,3-dioxygenase gene of Rhodococcus rhodochrous CTM: nucleotide sequence, comparison with isofunctional dioxygenases and evidence for an active-site histidine. Candidus, S., van Pée, K.H., Lingens, F. Microbiology (Reading, Engl.) (1994) [Pubmed]
  12. An integrated process for the production of toxic catechols from toxic phenols based on a designer biocatalyst. Held, M., Schmid, A., Kohler, H.P., Suske, W., Witholt, B., Wubbolts, M.G. Biotechnol. Bioeng. (1999) [Pubmed]
  13. Cloning of bacterial genes specifying degradation of 4-chlorobiphenyl from Pseudomonas putida OU83. Khan, A., Walia, S. Appl. Environ. Microbiol. (1989) [Pubmed]
  14. Directed evolution of extradiol dioxygenase by a novel in vivo DNA shuffling. Xu, S., Ju, J., Misono, H., Ohnishi, K. Gene (2006) [Pubmed]
  15. Nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene of Pseudomonas pseudoalcaligenes. Furukawa, K., Arimura, N., Miyazaki, T. J. Bacteriol. (1987) [Pubmed]
  16. From PCBs to highly toxic metabolites by the biphenyl pathway. Cámara, B., Herrera, C., González, M., Couve, E., Hofer, B., Seeger, M. Environ. Microbiol. (2004) [Pubmed]
  17. Pseudomonas putida KF715 bphABCD operon encoding biphenyl and polychlorinated biphenyl degradation: cloning, analysis, and expression in soil bacteria. Hayase, N., Taira, K., Furukawa, K. J. Bacteriol. (1990) [Pubmed]
  18. Molecular diagnostics and chemical analysis for assessing biodegradation of polychlorinated biphenyls in contaminated soils. Layton, A.C., Lajoie, C.A., Easter, J.P., Jernigan, R., Sanseverino, J., Sayler, G.S. J. Ind. Microbiol. (1994) [Pubmed]
  19. Cloning and sequencing of two tandem genes involved in degradation of 2,3-dihydroxybiphenyl to benzoic acid in the polychlorinated biphenyl-degrading soil bacterium Pseudomonas sp. strain KKS102. Kimbara, K., Hashimoto, T., Fukuda, M., Koana, T., Takagi, M., Oishi, M., Yano, K. J. Bacteriol. (1989) [Pubmed]
  20. Expression, localization, and functional analysis of polychlorinated biphenyl degradation genes cbpABCD of Pseudomonas putida. Khan, A.A., Walia, S.K. Appl. Environ. Microbiol. (1991) [Pubmed]
  21. Structure of catechol 2,3-dioxygenase gene encoded in chromosomal DNA of Pseudomonas putida KF715. Lee, J., Oh, J., Min, K.R., Kim, C.K., Min, K.H., Lee, K.S., Kim, Y.C., Lim, J.Y., Kim, Y. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  22. Crystal structure of Pseudomonas fluorescens 4-hydroxyphenylpyruvate dioxygenase: an enzyme involved in the tyrosine degradation pathway. Serre, L., Sailland, A., Sy, D., Boudec, P., Rolland, A., Pebay-Peyroula, E., Cohen-Addad, C. Structure (1999) [Pubmed]
  23. Purification and crystallization of 2,3-dihydroxybiphenyl 1,2-dioxygenase. Eltis, L.D., Hofmann, B., Hecht, H.J., Lünsdorf, H., Timmis, K.N. J. Biol. Chem. (1993) [Pubmed]
  24. Definitive evidence for monoanionic binding of 2,3-dihydroxybiphenyl to 2,3-dihydroxybiphenyl 1,2-dioxygenase from UV resonance Raman spectroscopy, UV/Vis absorption spectroscopy, and crystallography. Vaillancourt, F.H., Barbosa, C.J., Spiro, T.G., Bolin, J.T., Blades, M.W., Turner, R.F., Eltis, L.D. J. Am. Chem. Soc. (2002) [Pubmed]
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