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Chemical Compound Review

butein     (E)-1-(2,4-dihydroxyphenyl)- 3-(3,4...

Synonyms: CHEMBL128000, SureCN139243, B178_SIGMA, CHEBI:3237, CHEBI:310267, ...
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Disease relevance of butein


High impact information on butein


Associations of butein with other chemical compounds


  1. Inhibition by lipoxygenase inhibitors of 7-bromomethylbenz[a]anthracene-caused epidermal ornithine decarboxylase induction and skin tumor promotion in mice. Nakadate, T., Yamamoto, S., Aizu, E., Kato, R. Carcinogenesis (1989) [Pubmed]
  2. Butein (3,4,2',4'-tetrahydroxychalcone) ameliorates experimental anti-glomerular basement membrane antibody-associated glomerulonephritis (3). Hayashi, K., Nagamatsu, T., Honda, S., Suzuki, Y. Eur. J. Pharmacol. (1996) [Pubmed]
  3. Protective effects of hydroxychalcones on free radical-induced cell damage. Sogawa, S., Nihro, Y., Ueda, H., Miki, T., Matsumoto, H., Satoh, T. Biol. Pharm. Bull. (1994) [Pubmed]
  4. Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects. Aizu, E., Nakadate, T., Yamamoto, S., Kato, R. Carcinogenesis (1986) [Pubmed]
  5. Cyclooxygenase inhibitory flavonoids from the stem bark of Semecarpus anacardium Linn. Selvam, C., Jachak, S.M., Bhutani, K.K. Phytotherapy research : PTR. (2004) [Pubmed]
  6. Hypotensive effect of butein via the inhibition of angiotensin converting enzyme. Kang, D.G., Kim, Y.C., Sohn, E.J., Lee, Y.M., Lee, A.S., Yin, M.H., Lee, H.S. Biol. Pharm. Bull. (2003) [Pubmed]
  7. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. Pandey, M.K., Sandur, S.K., Sung, B., Sethi, G., Kunnumakkara, A.B., Aggarwal, B.B. J. Biol. Chem. (2007) [Pubmed]
  8. Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo. Rajendran, P., Ong, T.H., Chen, L., Li, F., Shanmugam, M.K., Vali, S., Abbasi, T., Kapoor, S., Sharma, A., Kumar, A.P., Hui, K.M., Sethi, G. Clin. Cancer Res. (2011) [Pubmed]
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