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Chemical Compound Review:

Bellidin 1,3,5,8-tetrahydroxyxanthen- 9-one

Synonyms: AC1NQYRG, CHEMBL184574, CCRIS 3853, AG-E-97223, SureCN9838546, ...

Jiang, D.J. et al., Matsushima, T. et al., Jiang, D.J. et al., Wang, C.Z. et al., Jiang, D.J. et al.

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Disease relevance of Demethylbellidifolin

Protective effects of demethylbellidifolin on myocardial ischemia-reperfusion injury in rats [1].

High impact information on Demethylbellidifolin

Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level [2].
The effect of demethylbellidifolin (DMB), a major compound of Swertia davidi Franch, on the adhesion of monocytes to endothelial cells induced by oxidized low-density lipoprotein (ox-LDL) was studied [2].
Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata [3].
Xanthydrol, gentisein, gentisin, isogentisin, 1-hydroxy-3,7-dimethoxyxanthone, 1,3,7-trimethoxyxanthone, desmethylbellidifolin, bellidifolin and dimethylbellidifolin were mutagenic, but unsubstituted xanthone was not mutagenic to TA100, TA98, TA97 and TA2637 with or without a metabolic activation system [4].
The present study examined the anti-oxidation and protective effects of demethylbellidifolin (DMB), a xanthone compound extracted from swertia davidi Franch, on endothelium [5].

References

Protective effects of demethylbellidifolin on myocardial ischemia-reperfusion injury in rats. Jiang, D.J., Tan, G.S., Zhou, Z.H., Xu, K.P., Ye, F., Li, Y.J. Planta Med. (2002) [Pubmed]
Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level. Jiang, D.J., Jiang, J.L., Tan, G.S., Huang, Z.Z., Deng, H.W., Li, Y.J. Planta Med. (2003) [Pubmed]
Phenylalanine-independent biosynthesis of 1,3,5,8-tetrahydroxyxanthone. A retrobiosynthetic NMR study with root cultures of Swertia chirata. Wang, C.Z., Maier, U.H., Keil, M., Zenk, M.H., Bacher, A., Rohdich, F., Eisenreich, W. Eur. J. Biochem. (2003) [Pubmed]
Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637. Matsushima, T., Araki, A., Yagame, O., Muramatsu, M., Koyama, K., Ohsawa, K., Natori, S., Tomimori, H. Mutat. Res. (1985) [Pubmed]
Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. Jiang, D.J., Jiang, J.L., Zhu, H.Q., Tan, G.S., Liu, S.Q., Xu, K.P., Li, Y.J. Journal of ethnopharmacology. (2004) [Pubmed]

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