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Chemical Compound Review:

Hypolaetin 2-(3,4-dihydroxyphenyl)- 5,7,8-trihydroxy...

Synonyms: AC1NQYT7, CHEBI:5837, CHEMBL1829395, LMPK12111397, C10078, ...

Moroney, M.A. et al., Alcaraz, M.J. et al., Gudej, J.

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Disease relevance of Hypolaetin

The newly identified plant-derived flavone-glycoside hypolaetin-8-glucoside, which has anti-inflammatory and gastric ulcer protective properties, and its corresponding aglycone, hypolaetin, were tested for effects on prostaglandin biosynthesis and degradation [1].

High impact information on Hypolaetin

The structures of the compounds were established on the basis of acid hydrolysis and spectroscopic methods (UV, (1)H-NMR, (13)C-NMR) as hypolaetin 8-glucoside and the new flavonoid sulphate - isoscutellarein 4'-methyl ether 8-glucoside-2''-SO (3)K [2].
Hypolaetin-8-glucoside was a weak but selective inhibitor of 5-lipoxygenase (IC50 56 microM vs 5-lipoxygenase; greater than 1000 microM vs cyclo-oxygenase), whereas the aglycone hypolaetin was a more potent and selective 5-lipoxygenase inhibitor (IC50 4.5 microM vs 70 microM) [3].

References

Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation. Alcaraz, M.J., Hoult, J.R. Biochem. Pharmacol. (1985) [Pubmed]
Flavonoids, Phenolic Acids and Coumarins from the Roots of Althaea officinalis. Gudej, J. Planta Med. (1991) [Pubmed]
Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids. Moroney, M.A., Alcaraz, M.J., Forder, R.A., Carey, F., Hoult, J.R. J. Pharm. Pharmacol. (1988) [Pubmed]

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