Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1NQYUJ 5,7,8-trihydroxy-2-(4- hydroxyphenyl)chrome...

Synonyms: CHEBI:6059, AG-F-47442, CTK4I4833, LMPK12111361, C10097, ...

Nagai, T. et al., Kamiya, K. et al., Gudej, J., Goniotaki, M. et al.

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Disease relevance of C10097

Isoscutellarein also inhibited the replication of influenza virus A/WSN/33 in Madin-Darby bovine kidney cells with 50% virus inhibitory dose at 16 nmol/well and influenza virus A/PR/8/34 in the allantoic sac of embryonated egg with little toxic effects [1].

High impact information on C10097

The structures of the compounds were established on the basis of acid hydrolysis and spectroscopic methods (UV, (1)H-NMR, (13)C-NMR) as hypolaetin 8-glucoside and the new flavonoid sulphate - isoscutellarein 4'-methyl ether 8-glucoside-2''-SO (3)K [2].
Liposomal isoscutellarein showed improved growth inhibiting activity against all cell lines tested in comparison with that of its free form, which was inactive (>100 microM) [3].
Five flavonoid glucuronides were obtained from the fruit of Helicteres isora, three of which were previously unknown compounds: isoscutellarein 4'-methyl ether 8-O-beta-D-glucuronide 6"-n-butyl ester. isoscutellarein 4'-methyl ether 8-O-beta-D-glucuronide 2", 4"-disulfate and isoscutellarein 8-O-beta-D-glucuronide 2",4"-disulfate [4].
Isoscutellarein (5,7,8,4'-tetrahydroxyflavone) from the leaf of Scutellaria baicalensis non-competitively inhibited (IC50, 20 microM) the hydrolysis of sodium p-nitrophenyl-N-acetyl-alpha-D-neuraminate by influenza virus sialidase with an apparent Ki value of 41 microM [1].

References

In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase. Nagai, T., Miyaichi, Y., Tomimori, T., Suzuki, Y., Yamada, H. Antiviral Res. (1992) [Pubmed]
Flavonoids, Phenolic Acids and Coumarins from the Roots of Althaea officinalis. Gudej, J. Planta Med. (1991) [Pubmed]
Encapsulation of naturally occurring flavonoids into liposomes: physicochemical properties and biological activity against human cancer cell lines. Goniotaki, M., Hatziantoniou, S., Dimas, K., Wagner, M., Demetzos, C. J. Pharm. Pharmacol. (2004) [Pubmed]
Flavonoid glucuronides from Helicteres isora. Kamiya, K., Saiki, Y., Hama, T., Fujimoto, Y., Endang, H., Umar, M., Satake, T. Phytochemistry (2001) [Pubmed]

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