Gene Review:
Alox5 - arachidonate 5-lipoxygenase
Rattus norvegicus
Synonyms:
5-LO, 5-lipoxygenase, Arachidonate 5-lipoxygenase
- Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. Jones, J.E., Walker, J.L., Song, Y., Weiss, N., Cardoso, W.V., Tuder, R.M., Loscalzo, J., Zhang, Y.Y. Am. J. Physiol. Heart Circ. Physiol. (2004)
- 5-lipoxygenase expression and activity in aorta from streptozotocin-induced diabetic rats. Hardy, G., Vergnaud, S., Lunardi, J., Peoc'h, M., Bessard, G., Stanke-Labesque, F. Prostaglandins Other Lipid Mediat. (2005)
- Prolonged exposure to lipopolysaccharide inhibits macrophage 5-lipoxygenase metabolism via induction of nitric oxide synthesis. Coffey, M.J., Phare, S.M., Peters-Golden, M. J. Immunol. (2000)
- Acute effects of the cys-leukotriene-1 receptor antagonist, montelukast, on experimental colitis in rats. Holma, R., Salmenperä, P., Riutta, A., Virtanen, I., Korpela, R., Vapaatalo, H. Eur. J. Pharmacol. (2001)
- How opioids inhibit GABA-mediated neurotransmission. Vaughan, C.W., Ingram, S.L., Connor, M.A., Christie, M.J. Nature (1997)
- Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Dixon, R.A., Diehl, R.E., Opas, E., Rands, E., Vickers, P.J., Evans, J.F., Gillard, J.W., Miller, D.K. Nature (1990)
- Identification and isolation of a membrane protein necessary for leukotriene production. Miller, D.K., Gillard, J.W., Vickers, P.J., Sadowski, S., Léveillé, C., Mancini, J.A., Charleson, P., Dixon, R.A., Ford-Hutchinson, A.W., Fortin, R. Nature (1990)
- Effects of dual inhibitor of cyclooxygenase and 5-lipoxygenase on acute necrotizing pancreatitis in rats. Kalyoncu, N.I., Alhan, E., Ercin, C., Kural, B.V. Hepatogastroenterology (2006)
- Exacerbation of experimental colitis by nonsteroidal anti-inflammatory drugs is not related to elevated leukotriene B4 synthesis. Wallace, J.L., Keenan, C.M., Gale, D., Shoupe, T.S. Gastroenterology (1992)
- The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats. McVey, D.C., Vigna, S.R. Gastroenterology (2005)
- Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease. Wallace, J.L., MacNaughton, W.K., Morris, G.P., Beck, P.L. Gastroenterology (1989)
- AMPA receptor phosphorylation is selectively regulated by constitutive phospholipase A(2) and 5-lipoxygenase activities. Ménard, C., Valastro, B., Martel, M.A., Chartier, E., Marineau, A., Baudry, M., Massicotte, G. Hippocampus. (2005)
- Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase. Balcarek, J.M., Theisen, T.W., Cook, M.N., Varrichio, A., Hwang, S.M., Strohsacker, M.W., Crooke, S.T. J. Biol. Chem. (1988)
- Down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to lipopolysaccharide. Brock, T.G. Adv. Exp. Med. Biol. (2002)
- Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation. Song, Y., Wei, E.Q., Zhang, W.P., Ge, Q.F., Liu, J.R., Wang, M.L., Huang, X.J., Hu, X., Chen, Z. Brain Res. (2006)
- Increased expression of cytosolic phospholipase A2, 5-lipoxygenase and 5-lipoxygenase-activating protein in rat peritoneal macrophages during ovalbumin-induced sensitization. Escoubet-Lozach, L., M'Rini, C., Rey, A., Béraud, M., Lepert, J.C., Courtade, M., Frisach, M.F., Pipy, B. Clin. Exp. Allergy (2001)
- Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs. Hosford, G.E., Koyanagi, K.S., Leung, W.I., Olson, D.M. Exp. Lung Res. (2002)
- Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Hsu, M.F., Lu, M.C., Tsao, L.T., Kuan, Y.H., Chen, C.C., Wang, J.P. Biochem. Pharmacol. (2004)
- Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: dual inhibitors of cyclooxygenases and lipoxygenases. Moreau, A., Rao, P.N., Knaus, E.E. Bioorg. Med. Chem. (2006)
- Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism. Coffey, M.J., Phare, S.M., Peters-Golden, M. Biochim. Biophys. Acta (2002)
- Augmentation of myocardial production of 15-epi-lipoxin-a4 by pioglitazone and atorvastatin in the rat. Birnbaum, Y., Ye, Y., Lin, Y., Freeberg, S.Y., Nishi, S.P., Martinez, J.D., Huang, M.H., Uretsky, B.F., Perez-Polo, J.R. Circulation (2006)
- 5-Lipoxygenase is involved in the angiotensin II-induced NAD(P)H-oxidase activation. Luchtefeld, M., Drexler, H., Schieffer, B. Biochem. Biophys. Res. Commun. (2003)
- Production of leukotrienes in gonadotropin-releasing hormone-stimulated pituitary cells: potential role in luteinizing hormone release. Kiesel, L., Przylipiak, A.F., Habenicht, A.J., Przylipiak, M.S., Runnebaum, B. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Induction of interleukin-6 release by interleukin-1 in rat anterior pituitary cells in vitro: evidence for an eicosanoid-dependent mechanism. Spangelo, B.L., Jarvis, W.D., Judd, A.M., MacLeod, R.M. Endocrinology (1991)
- Suppression of leukotriene formation in RBL-2H3 cells that overexpressed phospholipid hydroperoxide glutathione peroxidase. Imai, H., Narashima, K., Arai, M., Sakamoto, H., Chiba, N., Nakagawa, Y. J. Biol. Chem. (1998)
- Reduced release of leukotrienes B4 and C4 from alveolar macrophages of rats with silicosis. Mohr, C., Davis, G.S., Graebner, C., Amann, S., Hemenway, D.R., Gemsa, D. Am. J. Respir. Cell Mol. Biol. (1992)
- Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation. Goodman, Y., Steiner, M.R., Steiner, S.M., Mattson, M.P. Brain Res. (1994)
- Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission. St-Gelais, F., Ménard, C., Congar, P., Trudeau, L.E., Massicotte, G. Hippocampus. (2004)
- Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells. Won, J.S., Im, Y.B., Khan, M., Singh, A.K., Singh, I. Glia (2005)
- Vascular effects of 7-epiclusianone, a prenylated benzophenone from Rheedia gardneriana, on the rat aorta. Cruz, A.J., Lemos, V.S., dos Santos, M.H., Nagem, T.J., Cortes, S.F. Phytomedicine (2006)
- Mesangial cell immune injury. Hemodynamic role of leukocyte- and platelet-derived eicosanoids. Bresnahan, B.A., Wu, S., Fenoy, F.J., Roman, R.J., Lianos, E.A. J. Clin. Invest. (1992)
- Hepatocyte-derived cysteinyl leukotrienes modulate vascular tone in experimental cirrhosis. Titos, E., Clària, J., Bataller, R., Bosch-Marcé, M., Ginès, P., Jiménez, W., Arroyo, V., Rivera, F., Rodés, J. Gastroenterology (2000)