Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Castanin 7-hydroxy-6-methoxy-3-(4...

Synonyms: Afromosin, Afrormosin, AC1NQYXM, CHEMBL464404, SureCN572274, ...

Halabalaki, M. et al., Gyémánt, N. et al.

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High impact information on C10199

Fractionation of the neutral extract of Onobrychis ebenoides (Leguminosae) yielded a new isoflavone, named ebenosin (1), in addition to the known ones, afrormosin (2), formononetin (3) and daidzein (4) [1].
In antiproliferative assay, afrormosin, amorphigenin, chrysin and rotenone exhibited the strongest antiproliferative effects in L5178 (max. ID50: 19.70) and MDA-MB-231 cell lines (max. ID50: 55.47) [2].

References

Estrogenic activity of isoflavonoids from Onobrychis ebenoides. Halabalaki, M., Alexi, X., Aligiannis, N., Lambrinidis, G., Pratsinis, H., Florentin, I., Mitakou, S., Mikros, E., Skaltsounis, A.L., Alexis, M.N. Planta Med. (2006) [Pubmed]
In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. Gyémánt, N., Tanaka, M., Antus, S., Hohmann, J., Csuka, O., Mándoky, L., Molnár, J. In Vivo (2005) [Pubmed]

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