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Chemical Compound Review

Formononetol     7-hydroxy-3-(4- methoxyphenyl)chromen-4-one

Synonyms: formononetin, Biochanin B, PubChem9850, AC1NQWYT, SPECTRUM102007, ...
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Disease relevance of NSC 93360


High impact information on NSC 93360


Chemical compound and disease context of NSC 93360


Biological context of NSC 93360


Anatomical context of NSC 93360


Associations of NSC 93360 with other chemical compounds


Gene context of NSC 93360


Analytical, diagnostic and therapeutic context of NSC 93360


  1. Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in leguminous isoflavone biosynthesis. Akashi, T., Aoki, T., Ayabe, S. Plant Physiol. (2005) [Pubmed]
  2. Radioimmunoassay determination of formononetin in murine plasma and mammary glandular tissue. Wang, W. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  3. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Akashi, T., Sawada, Y., Shimada, N., Sakurai, N., Aoki, T., Ayabe, S. Plant Cell Physiol. (2003) [Pubmed]
  4. Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity. Park, J., Kim, S.H., Cho, D., Kim, T.S. Immunology (2005) [Pubmed]
  5. Phytoestrogens have agonistic and combinatorial effects on estrogen-responsive gene expression in MCF-7 human breast cancer cells. Willard, S.T., Frawley, L.S. Endocrine (1998) [Pubmed]
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  8. Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates. Jia, X., Chen, J., Lin, H., Hu, M. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  9. Absorption in humans of isoflavones from soy and red clover is similar. Tsunoda, N., Pomeroy, S., Nestel, P. J. Nutr. (2002) [Pubmed]
  10. Analysis of thirteen populations of black cohosh for formononetin. Kennelly, E.J., Baggett, S., Nuntanakorn, P., Ososki, A.L., Mori, S.A., Duke, J., Coleton, M., Kronenberg, F. Phytomedicine (2002) [Pubmed]
  11. Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study. Tedeschi-Blok, N., Lee, M., Sison, J.D., Miike, R., Wrensch, M. BMC Cancer (2006) [Pubmed]
  12. CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase. Akashi, T., Aoki, T., Ayabe, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  13. Human serum albumin interaction with formononetin studied using fluorescence anisotropy, FT-IR spectroscopy, and molecular modeling methods. Li, Y., He, W., Dong, Y., Sheng, F., Hu, Z. Bioorg. Med. Chem. (2006) [Pubmed]
  14. Isoflavones in several clover species and in milk from goats fed clovers. Sakakibara, H., Viala, D., Ollier, A., Combeau, A., Besle, J.M. Biofactors (2004) [Pubmed]
  15. In vitro estrogenic activity of formononetin by two bioassay systems. Ji, Z.N., Zhao, W.Y., Liao, G.R., Choi, R.C., Lo, C.K., Dong, T.T., Tsim, K.W. Gynecol. Endocrinol. (2006) [Pubmed]
  16. Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Teede, H.J., McGrath, B.P., DeSilva, L., Cehun, M., Fassoulakis, A., Nestel, P.J. Arterioscler. Thromb. Vasc. Biol. (2003) [Pubmed]
  17. Clinical changes in ovariectomized ewes exposed to phytoestrogens and 17 beta-estradiol implants. Nwannenna, A.I., Lundh, T.J., Madej, A., Fredriksson, G., Björnhag, G. Proc. Soc. Exp. Biol. Med. (1995) [Pubmed]
  18. Proliferative response of mammary glandular tissue to formononetin. Wang, W., Tanaka, Y., Han, Z., Higuchi, C.M. Nutrition and cancer. (1995) [Pubmed]
  19. Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model. Chen, J., Lin, H., Hu, M. Cancer Chemother. Pharmacol. (2005) [Pubmed]
  20. Disposition of Flavonoids via Enteric Recycling: Structural Effects and Lack of Correlations between in Vitro and in Situ Metabolic Properties. Wang, S.W., Chen, J., Jia, X., Tam, V.H., Hu, M. Drug Metab. Dispos. (2006) [Pubmed]
  21. Determination of isoflavones in dietary supplements containing soy, Red Clover and kudzu: extraction followed by basic or acid hydrolysis. Delmonte, P., Perry, J., Rader, J.I. Journal of chromatography. A. (2006) [Pubmed]
  22. Estrogenic activity of isoflavonoids from Onobrychis ebenoides. Halabalaki, M., Alexi, X., Aligiannis, N., Lambrinidis, G., Pratsinis, H., Florentin, I., Mitakou, S., Mikros, E., Skaltsounis, A.L., Alexis, M.N. Planta Med. (2006) [Pubmed]
  23. Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan. Thompson, L.U., Boucher, B.A., Liu, Z., Cotterchio, M., Kreiger, N. Nutrition and cancer. (2006) [Pubmed]
  24. Elicitor-induced changes in isoflavonoid metabolism in red clover roots. Tebayashi , S., Ishihara, A., Iwamura, H. J. Exp. Bot. (2001) [Pubmed]
  25. In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells. Gyémánt, N., Tanaka, M., Antus, S., Hohmann, J., Csuka, O., Mándoky, L., Molnár, J. In Vivo (2005) [Pubmed]
  26. Interaction of phytoestrogens with estrogen receptors alpha and beta (II). Morito, K., Aomori, T., Hirose, T., Kinjo, J., Hasegawa, J., Ogawa, S., Inoue, S., Muramatsu, M., Masamune, Y. Biol. Pharm. Bull. (2002) [Pubmed]
  27. Analysis of formononetin from black cohosh (Actaea racemosa). Jiang, B., Kronenberg, F., Balick, M.J., Kennelly, E.J. Phytomedicine (2006) [Pubmed]
  28. Isoflavone content of infant foods and formulas. Knight, D.C., Eden, J.A., Huang, J.L., Waring, M.A. Journal of paediatrics and child health. (1998) [Pubmed]
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