The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Daidzeol     7-hydroxy-3-(4- hydroxyphenyl)chromen-4-one

Synonyms: Diadzein, daidzein, Isoaurostatin, UPCMLD-DP052, Lopac-D-7802, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C10208


Psychiatry related information on C10208


High impact information on C10208


Chemical compound and disease context of C10208

  • Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice [15].
  • The present study was conducted to determine if genistein and daidzein regulate hepatocyte cholesterol metabolism and apolipoprotein (apo) B secretion in cultured human hepatoma (HepG2) cells [16].
  • The aim of our study was to investigate the proliferative effects and mode of action of the phytoestrogens genistein, daidzein and coumestrol on TAM-sensitive (-s) and resistant (-r) breast cancer cells under in vitro conditions designed to mimic the hormonal environment of the pre- and post-menopausal breast [17].
  • METHODS: Effects of endothelial-denudation, and pretreatment with with 100 microM L-N(G)-nitroarginine methyl ester (L-NAME) and/or 10 microM indomethacin on relaxation of PE (1 microM)-preconstricted contractures by genistein (1-100 microM) and daidzein (3-100 microM) were assessed by measuring isometric force development by rat arterial rings [18].
  • Genistein, biochanin-A, and daidzein, the predominant soy isoflavones, have been reported to lower the risk of cancer, but it is not known whether they protect against human hepatoma cancer [19].

Biological context of C10208


Anatomical context of C10208


Associations of C10208 with other chemical compounds


Gene context of C10208


Analytical, diagnostic and therapeutic context of C10208

  • Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients [3].
  • HPLC fractionation and enzymatic assay of the soybean extract showed that the components responsible for inhibition of TPO-catalyzed reactions coeluted with daidzein and genistein [36].
  • During validation studies of the uterotrophic bioassay, diet samples from 20 participating laboratories were collected and analyzed for three major phytoestrogens: GN, daidzein (DN), and coumestrol (CM) [37].
  • A dramatic rise in plasma isoflavone concentrations was observed after supplementation in the soy protein group, the levels reaching 907 +/- 245 nmol/L for genistein (a 110-fold increase) and 498 +/- 102 nmol/L for daidzein (a 150-fold increase) as measured by isotope dilution gas chromatography - mass spectrometry [38].
  • This case-control study in China evaluated the effect of soy food consumption and isoflavones (genistein and daidzein) on the risk of prostate cancer [39].


  1. Elicitor-induced association of isoflavone O-methyltransferase with endomembranes prevents the formation and 7-O-methylation of daidzein during isoflavonoid phytoalexin biosynthesis. Liu, C.J., Dixon, R.A. Plant Cell (2001) [Pubmed]
  2. Daidzin and daidzein suppress free-choice ethanol intake by Syrian golden hamsters. Keung, W.M., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Serum levels and metabolic clearance of the isoflavones genistein and daidzein in hemodialysis patients. Fanti, P., Sawaya, B.P., Custer, L.J., Franke, A.A. J. Am. Soc. Nephrol. (1999) [Pubmed]
  4. Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Setchell, K.D., Lydeking-Olsen, E. Am. J. Clin. Nutr. (2003) [Pubmed]
  5. Dietary phytoestrogen intake and premenopausal breast cancer risk in a German case-control study. Linseisen, J., Piller, R., Hermann, S., Chang-Claude, J. Int. J. Cancer (2004) [Pubmed]
  6. Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in caucasian men. Hedlund, T.E., Maroni, P.D., Ferucci, P.G., Dayton, R., Barnes, S., Jones, K., Moore, R., Ogden, L.G., Wähälä, K., Sackett, H.M., Gray, K.J. J. Nutr. (2005) [Pubmed]
  7. Phytoestrogen intake and prostate cancer: a case-control study using a new database. Strom, S.S., Yamamura, Y., Duphorne, C.M., Spitz, M.R., Babaian, R.J., Pillow, P.C., Hursting, S.D. Nutrition and cancer. (1999) [Pubmed]
  8. Daidzein activates choline acetyltransferase from MC-IXC cells and improves drug-induced amnesia. Heo, H.J., Suh, Y.M., Kim, M.J., Choi, S.J., Mun, N.S., Kim, H.K., Kim, E., Kim, C.J., Cho, H.Y., Kim, Y.J., Shin, D.H. Biosci. Biotechnol. Biochem. (2006) [Pubmed]
  9. Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. Keung, W.M., Vallee, B.L. EXS. (1994) [Pubmed]
  10. Dietary estrogens--a probable cause of infertility and liver disease in captive cheetahs. Setchell, K.D., Gosselin, S.J., Welsh, M.B., Johnston, J.O., Balistreri, W.F., Kramer, L.W., Dresser, B.L., Tarr, M.J. Gastroenterology (1987) [Pubmed]
  11. The phytoestrogen genistein induces thymic and immune changes: a human health concern? Yellayi, S., Naaz, A., Szewczykowski, M.A., Sato, T., Woods, J.A., Chang, J., Segre, M., Allred, C.D., Helferich, W.G., Cooke, P.S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  12. Thrombin induces the preproendothelin-1 gene in endothelial cells by a protein tyrosine kinase-linked mechanism. Marsen, T.A., Simonson, M.S., Dunn, M.J. Circ. Res. (1995) [Pubmed]
  13. Phospholipase D activation in hepatocyte growth factor-stimulated rat hepatocytes mediates the expressions of c-jun and c-fos: involvement of protein tyrosine kinase, protein kinase C, and Ca2+. Adachi, T., Nakashima, S., Saji, S., Nakamura, T., Nozawa, Y. Hepatology (1996) [Pubmed]
  14. Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Yanagihara, K., Ito, A., Toge, T., Numoto, M. Cancer Res. (1993) [Pubmed]
  15. Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice. Ju, Y.H., Fultz, J., Allred, K.F., Doerge, D.R., Helferich, W.G. Carcinogenesis (2006) [Pubmed]
  16. Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Borradaile, N.M., de Dreu, L.E., Wilcox, L.J., Edwards, J.Y., Huff, M.W. Biochem. J. (2002) [Pubmed]
  17. Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells in vitro. Limer, J.L., Parkes, A.T., Speirs, V. Int. J. Cancer (2006) [Pubmed]
  18. Endothelium-dependent relaxation of rat aorta and main pulmonary artery by the phytoestrogens genistein and daidzein. Mishra, S.K., Abbot, S.E., Choudhury, Z., Cheng, M., Khatab, N., Maycock, N.J., Zavery, A., Aaronson, P.I. Cardiovasc. Res. (2000) [Pubmed]
  19. Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-XL downregulation, and Cdc2 kinase activity. Su, S.J., Chow, N.H., Kung, M.L., Hung, T.C., Chang, K.L. Nutrition and cancer. (2003) [Pubmed]
  20. ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets. Sargeant, P., Farndale, R.W., Sage, S.O. J. Biol. Chem. (1993) [Pubmed]
  21. The balance between concurrent activation of ERs and PPARs determines daidzein-induced osteogenesis and adipogenesis. Dang, Z., Löwik, C.W. J. Bone Miner. Res. (2004) [Pubmed]
  22. Down-regulation of osteoclast differentiation by daidzein via caspase 3. Rassi, C.M., Lieberherr, M., Chaumaz, G., Pointillart, A., Cournot, G. J. Bone Miner. Res. (2002) [Pubmed]
  23. Human thyroid phenol sulfotransferase enzymes 1A1 and 1A3: activities in normal and diseased thyroid glands, and inhibition by thyroid hormones and phytoestrogens. Ebmeier, C.C., Anderson, R.J. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  24. Soy isoflavonoids exhibit in vitro biological activities of loop diuretics. Martínez, R.M., Giménez, I., Lou, J.M., Mayoral, J.A., Alda, J.O. Am. J. Clin. Nutr. (1998) [Pubmed]
  25. Signal transduction-mediated activation of the aryl hydrocarbon receptor in rat hepatoma H4IIE cells. Backlund, M., Johansson, I., Mkrtchian, S., Ingelman-Sundberg, M. J. Biol. Chem. (1997) [Pubmed]
  26. Effects of isoflavones on alcohol pharmacokinetics and alcohol-drinking behavior in rats. Lin, R.C., Li, T.K. Am. J. Clin. Nutr. (1998) [Pubmed]
  27. Genistein, the dietary-derived angiogenesis inhibitor, prevents LDL oxidation and protects endothelial cells from damage by atherogenic LDL. Kapiotis, S., Hermann, M., Held, I., Seelos, C., Ehringer, H., Gmeiner, B.M. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  28. Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Zubik, L., Meydani, M. Am. J. Clin. Nutr. (2003) [Pubmed]
  29. Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage. Shelnutt, S.R., Cimino, C.O., Wiggins, P.A., Ronis, M.J., Badger, T.M. Am. J. Clin. Nutr. (2002) [Pubmed]
  30. Dual effects of daidzein, a soy isoflavone, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. Liu, M., Yanagihara, N., Toyohira, Y., Tsutsui, M., Ueno, S., Shinohara, Y. Endocrinology (2007) [Pubmed]
  31. Isoflavones modulate the glucuronidation of estradiol in human liver microsomes. Pfeiffer, E., Treiling, C.R., Hoehle, S.I., Metzler, M. Carcinogenesis (2005) [Pubmed]
  32. Daidzein-sulfate metabolites affect transcriptional and antiproliferative activities of estrogen receptor-beta in cultured human cancer cells. Totta, P., Acconcia, F., Virgili, F., Cassidy, A., Weinberg, P.D., Rimbach, G., Marino, M. J. Nutr. (2005) [Pubmed]
  33. Effects of phytoestrogens genistein and daidzein on prostacyclin production by human endothelial cells. Hermenegildo, C., Oviedo, P.J., García-Pérez, M.A., Tarín, J.J., Cano, A. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  34. Effects of protein tyrosine kinase inhibitors on cytokine-induced adhesion molecule expression by human umbilical vein endothelial cells. May, M.J., Wheeler-Jones, C.P., Pearson, J.D. Br. J. Pharmacol. (1996) [Pubmed]
  35. Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity. Park, J., Kim, S.H., Cho, D., Kim, T.S. Immunology (2005) [Pubmed]
  36. Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action. Divi, R.L., Chang, H.C., Doerge, D.R. Biochem. Pharmacol. (1997) [Pubmed]
  37. The OECD program to validate the rat uterotrophic bioassay. Phase 2: dietary phytoestrogen analyses. Owens, W., Ashby, J., Odum, J., Onyon, L. Environ. Health Perspect. (2003) [Pubmed]
  38. A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. Gooderham, M.H., Adlercreutz, H., Ojala, S.T., Wähälä, K., Holub, B.J. J. Nutr. (1996) [Pubmed]
  39. Soy and isoflavone consumption in relation to prostate cancer risk in China. Lee, M.M., Gomez, S.L., Chang, J.S., Wey, M., Wang, R.T., Hsing, A.W. Cancer Epidemiol. Biomarkers Prev. (2003) [Pubmed]
WikiGenes - Universities