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Chemical Compound Review:

omega-9 Hpaa (5Z,8Z,10E,14Z)-12- hydroperoxyicosa-5,8,10...

Synonyms: LS-176613, AC1NR1OW, 12-Oohete, 12-Hpete, omega-9-Hydroperoxyarachidonic acid, ...

Goetzl, E.J. et al., Liu, C. et al., Hashimoto, Y. et al.

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Disease relevance of Arachidonic acid omega-9 hydroperoxide

12-LOX enzyme activity assays showed that Rz significantly reduced the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid production in human erythroleukemia cells; this effect was sustained for up to 6 months in cell culture [1].

High impact information on Arachidonic acid omega-9 hydroperoxide

Time-dependent inhibition of the cyclooxygenase pathway by 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid [2].
Furthermore, 12-OOHETE may activate neutrophils by pathways not available to 12-OHETE [3].
The release of neutrophil lysosomal enzymes by the chemotactic fragments of C5 was augmented substantially by 12-OOHETE, while 12-OHETE had only a marginal effect [3].

Associations of Arachidonic acid omega-9 hydroperoxide with other chemical compounds

The concentration of guanosine 3':5' cyclic monophosphate (cGMP) in neutrophils was increased to the same plateau level by 5 ng/ml of 12-OOHETE and by 50 ng/ml of 12-OHETE [3].

References

Ribozyme-mediated suppression of platelet type 12 lipoxygenase in human erythroleukemia cells. Liu, C., Sun, L.Q., Tien, P. Cancer Gene Ther. (2000) [Pubmed]
Time-dependent inhibition of the cyclooxygenase pathway by 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid. Hashimoto, Y., Naito, C., Teramoto, T., Kato, H., Kinoshita, M., Kawamura, M., Hayashi, H., Oka, H. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
Unique aspects of the modulation of human neutrophil function by 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid. Goetzl, E.J., Hill, H.R., Gorman, R.R. Prostaglandins (1980) [Pubmed]

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