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Chemical Compound Review:

Preclamol 3-[(3R)-1-propyl-3- piperidyl]phenol

Synonyms: CHEMBL7549, SureCN1240854, CHEBI:102724, CCG-205076, Lopac0_000996, ...

Svensson, K. et al., Sánchez, C. et al., Pirtosek, Z. et al., Metman, L.V. et al., Hillegaart, V. et al.

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Disease relevance of Preclamol

The partial DA receptor agonist preclamol, (-)-3-PPP (50-200 mumol/kg, s.c.) partially reversed the catalepsy induced by the dopamine (DA) receptor antagonists haloperidol (5.3 mumol/kg, i.p.) and raclopride (20.1 mumol/kg, i.p.) in rats [1].
Motor effects of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine (preclamol) in Parkinson's disease [2].
Apomorphine-, quinelorane- and talipexole-induced hypothermia was reversed by terguride and preclamol, whereas EMD 23448 partially reversed the apomorphine-induced hypothermia [3].
Preclamol had a mild but unequivocal antiakinetic effect, less than that caused by subcutaneous apomorphine, but it provoked less dyskinesia [4].

Psychiatry related information on Preclamol

Raclopride and preclamol are about equipotent in suppressing exploratory locomotor activity [5].

High impact information on Preclamol

Finally, the elevation of serum prolactin in rats induced by haloperidol (0.25 mumol/kg, i.p.) was significantly antagonized by co-administration of preclamol (39 mumol/kg, s.c.). These results show that partial DA agonists can reverse both behavioral, biochemical and neuroendocrine effects of neuroleptics [1].

References

Partial dopamine receptor agonists reverse behavioral, biochemical and neuroendocrine effects of neuroleptics in the rat: potential treatment of extrapyramidal side effects. Svensson, K., Eriksson, E., Carlsson, A. Neuropharmacology (1993) [Pubmed]
Motor effects of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine (preclamol) in Parkinson's disease. Metman, L.V., Sethy, V.H., Roberts, J.R., Bravi, D., Hoff, J.I., Mouradian, M.M., Chase, T.N. Mov. Disord. (1994) [Pubmed]
Effects on body temperature in mice differentiate between dopamine D2 receptor agonists with high and low efficacies. Sánchez, C., Arnt, J. Eur. J. Pharmacol. (1992) [Pubmed]
Preclamol and parkinsonian fluctuations. Pirtosek, Z., Merello, M., Carlsson, A., Stern, G. Clinical neuropharmacology. (1993) [Pubmed]
Effects of raclopride on exploratory locomotor activity, treadmill locomotion, conditioned avoidance behaviour and catalepsy in rats: behavioural profile comparisons between raclopride, haloperidol and preclamol. Hillegaart, V., Ahlenius, S. Pharmacol. Toxicol. (1987) [Pubmed]

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