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Chemical Compound Review:

AC1NST3K (4R,6aR,8aR,12S,12aR,14bS)-3- hydroxy-4,6a...

Synonyms:

Huang, M.T. et al., Frank, A. et al., Shah, S.A. et al., Liu, J.J. et al., Bore, L. et al.

Shah, Rathod, Suhagia, Patel, Parmar, Shah, Vaishnavi, Huang, Badmaev, Ding, Liu, Xie, Ho,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on beta-Boswellic acid

HT-29 cells were treated with beta-boswellic acid (BA), keto-beta-boswellic acid (K-BA) and acetyl-keto-beta-boswellic acid (AK-BA), respectively [1].
Synthesis of beta-Boswellic acid analogues with a carboxyl group at C-17 isolated from the bark of Schefflera octophylla [2].
LC/LC/ESI-MS fingerprint analyses of the boswellic acids 11-keto-beta-boswellic acid, alpha-boswellic acid, beta-boswellic acid and their 3-O-acylated derivatives were used for the authentication of the commercially obtained frankincense samples [3].
Boswellin (BE), a methanol extract of the gum resin exudate of Boswellia serrata, contains naturally occurring triterpenoids, beta-boswellic acid and its structural related derivatives, has been used as a traditional medicine for the treatment of inflammatory and arthritic diseases [4].
Addition of pure beta-boswellic acid, 3-O-acetyl-beta-boswellic acid, 11-keto-beta-boswellic acid or 3-O-acetyl-11-keto-beta-boswellic acid to human leukemia HL-60 cell culture inhibited DNA synthesis in HL-60 cells in a dose-dependent manner with IC50 values ranging from 0.6 to 7.1 microM [4].

Analytical, diagnostic and therapeutic context of beta-Boswellic acid

Estimation of boswellic acids from market formulations of Boswellia serrata extract and 11-keto beta-boswellic acid in human plasma by high-performance thin-layer chromatography [5].

References

Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Liu, J.J., Nilsson, A., Oredsson, S., Badmaev, V., Zhao, W.Z., Duan, R.D. Carcinogenesis (2002) [Pubmed]
Synthesis of beta-Boswellic acid analogues with a carboxyl group at C-17 isolated from the bark of Schefflera octophylla. Bore, L., Honda, T., Gribble, G.W. J. Org. Chem. (2000) [Pubmed]
Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. Frank, A., Unger, M. Journal of chromatography. A. (2006) [Pubmed]
Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Huang, M.T., Badmaev, V., Ding, Y., Liu, Y., Xie, J.G., Ho, C.T. Biofactors (2000) [Pubmed]
Estimation of boswellic acids from market formulations of Boswellia serrata extract and 11-keto beta-boswellic acid in human plasma by high-performance thin-layer chromatography. Shah, S.A., Rathod, I.S., Suhagia, B.N., Patel, D.A., Parmar, V.K., Shah, B.K., Vaishnavi, V.M. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2007) [Pubmed]

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