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MeSH Review

Medicine, Traditional

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Disease relevance of Medicine, Traditional

  • Extracts from certain Mexican Indian medicinal plants used in traditional indigenous medicine for the treatment of inflammations contain sequiterpene lactones (SLs), which specifically inhibit the transcription factor NF-kappa B (Bork, P. M., Schmitz, M. L., Kuhnt, M., Escher, C., and Heinrich, M. (1997) FEBS Lett. 402, 85-90) [1].
  • Curcumin (diferuloylmethane), an anti-inflammatory agent used in traditional medicine, has been shown to suppress cellular transformation, proliferation, invasion, angiogenesis, and metastasis through a mechanism not fully understood [2].
  • We investigated the mechanisms of action of S-petasin and S-isopetasin, from Petasites formosanus Kitamura which is used as a folk medicine for treating hypertension, tumors, and asthma in Taiwan. The tension changes of tracheal segments were isometrically recorded on a polygraph [3].
  • Previous studies showed that Pien Tze Huang, a Chinese folk medicine well known for its therapeutic activity in treating liver diseases, protected the liver against carbon tetrachloride (CCl4)-induced damage in mice [4].
  • This study revealed that crocetin, which is an important ingredient of diet in India and also used in various systems of indigenous medicine, is helpful in preventing Parkinsonism and has therapeutic potential in combating this devastating neurologic disorder [5].

Psychiatry related information on Medicine, Traditional


High impact information on Medicine, Traditional


Chemical compound and disease context of Medicine, Traditional


Biological context of Medicine, Traditional


Anatomical context of Medicine, Traditional


Associations of Medicine, Traditional with chemical compounds

  • Piceatannol, a naturally occurring analog of resveratrol, was previously identified as the active ingredient in herbal preparations in folk medicine and as an inhibitor of p72(Syk) [26].
  • Studies on the Taiwan folk medicine. VI. Studies on onitin [27].
  • In the present study, 51 South African plant species were selected on the basis of their use in traditional medicine and crude extracts were sequentially prepared from different dried plant parts using dichloromethane followed by 90% methanol [28].
  • Kaempferol 3-O-[alpha-L-rhamnopyranosyl (1-->6)-beta-D-glucopyranoside] and kaempferol 3-O-[beta-D-glucopyranoside] were isolated from the leaves of Hedyosmum bonplandianum H.B.K. (Chloranthaceae), which is used in Colombian folk medicine as an analgesic [29].
  • We present a case of lipoid pneumonia from ingestion of squalene, a derivative of shark liver oil, a popular over-the-counter Asian folk remedy [30].

Gene context of Medicine, Traditional

  • A potential source for new 5-lipoxygenase inhibitors is undoubtedly provided by the abundance of medicinal plants used in traditional medicine [31].
  • The observed induction and inhibition of CYP enzymes by natural products in the presence of a prescribed drug has (among other reasons) led to the general acceptance that natural therapies can have adverse effects, contrary to the popular beliefs in countries where there is an active practice of ethnomedicine [32].
  • Madimadi, a Korean folk medicine, has been applied to treat rheumatoid arthritis (RA) [33].
  • Madimadi, Korean folk medicine, blocks TNF-alpha, IL-1beta, and IL-8 production by activated human immune cells [33].
  • Thus, further phytochemical and pharmacological studies may lead to isolation and structural identification of an inhibitor of iNOS from C. tricuspidata, which has been used as a traditional medicine for curing inflammation [34].

Analytical, diagnostic and therapeutic context of Medicine, Traditional


  1. Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta. Hehner, S.P., Heinrich, M., Bork, P.M., Vogt, M., Ratter, F., Lehmann, V., Schulze-Osthoff, K., Dröge, W., Schmitz, M.L. J. Biol. Chem. (1998) [Pubmed]
  2. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Aggarwal, S., Ichikawa, H., Takada, Y., Sandur, S.K., Shishodia, S., Aggarwal, B.B. Mol. Pharmacol. (2006) [Pubmed]
  3. Mechanisms of relaxant action of S-petasin and S-isopetasin, sesquiterpenes of Petasites formosanus, in isolated guinea pig trachea. Ko, W.C., Lei, C.B., Lin, Y.L., Chen, C.F. Planta Med. (2001) [Pubmed]
  4. Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities. Chan, W.Y., Chau, F.T., Lee, K.K., Kwong, W.H., Yew, D.T. Human & experimental toxicology. (2004) [Pubmed]
  5. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Ahmad, A.S., Ansari, M.A., Ahmad, M., Saleem, S., Yousuf, S., Hoda, M.N., Islam, F. Pharmacol. Biochem. Behav. (2005) [Pubmed]
  6. Evaluation of the anticonvulsant activity of the essential oil of Eugenia caryophyllata in male mice. Pourgholami, M.H., Kamalinejad, M., Javadi, M., Majzoob, S., Sayyah, M. Journal of ethnopharmacology. (1999) [Pubmed]
  7. Antipruritic effect of ginsenoside rb1 and compound k in scratching behavior mouse models. Shin, Y.W., Kim, D.H. J. Pharmacol. Sci. (2005) [Pubmed]
  8. Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes. Han, L.K., Zheng, Y.N., Yoshikawa, M., Okuda, H., Kimura, Y. BMC complementary and alternative medicine [electronic resource]. (2005) [Pubmed]
  9. Chronic camphor ingestion mimicking Reye's syndrome. Jimenez, J.F., Brown, A.L., Arnold, W.C., Byrne, W.J. Gastroenterology (1983) [Pubmed]
  10. Herbal medicines today and the roots of modern pharmacology. Goldman, P. Ann. Intern. Med. (2001) [Pubmed]
  11. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. Xia, Y.F., Ye, B.Q., Li, Y.D., Wang, J.G., He, X.J., Lin, X., Yao, X., Ma, D., Slungaard, A., Hebbel, R.P., Key, N.S., Geng, J.G. J. Immunol. (2004) [Pubmed]
  12. Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells. Cao, E.H., Liu, X.Q., Wang, J.J., Xu, N.F. Free Radic. Biol. Med. (1996) [Pubmed]
  13. Subcutaneous injection of mercury: "warding off evil". Prasad, V.L. Environ. Health Perspect. (2004) [Pubmed]
  14. The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation. Freitas, A.M., Schor, N., Boim, M.A. BJU international. (2002) [Pubmed]
  15. Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis. Hasrat, J.A., Pieters, L., Claeys, M., Vlietinck, A., De Backer, J.P., Vauquelin, G. J. Nat. Prod. (1997) [Pubmed]
  16. Antimicrobial constituents of Rhus glabra. Saxena, G., McCutcheon, A.R., Farmer, S., Towers, G.H., Hancock, R.E. Journal of ethnopharmacology. (1994) [Pubmed]
  17. Effects of Artemisia pallens Wall. on blood glucose levels in normal and alloxan-induced diabetic rats. Subramoniam, A., Pushpangadan, P., Rajasekharan, S., Evans, D.A., Latha, P.G., Valsaraj, R. Journal of ethnopharmacology. (1996) [Pubmed]
  18. Allergic conjunctivitis to chamomile tea. Subiza, J., Subiza, J.L., Alonso, M., Hinojosa, M., Garcia, R., Jerez, M., Subiza, E. Annals of allergy. (1990) [Pubmed]
  19. Hmong folk remedies: limited acetylation of opium by aspirin and acetaminophen. Smith, R.M., Nelsen, L.A. J. Forensic Sci. (1991) [Pubmed]
  20. The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: preliminary experimental study. Puri, D. Journal of ethnopharmacology. (2001) [Pubmed]
  21. Repeated treatment with the traditional medicine Unsei-in inhibits substance P-induced itch-associated responses through downregulation of the expression of nitric oxide synthase 1 in mice. Andoh, T., Al-Akeel, A., Tsujii, K., Nojima, H., Kuraishi, Y. J. Pharmacol. Sci. (2004) [Pubmed]
  22. Studies on the Taiwan folk medicine; III. A smooth muscle relaxant from Onychium siliculosum, onitin. Ho, S.T., Yang, M.S., Wu, T.S., Wang, C.H. Planta Med. (1985) [Pubmed]
  23. Anti-tumor and anti-carcinogenic activities of triterpenoid, beta-boswellic acid. Huang, M.T., Badmaev, V., Ding, Y., Liu, Y., Xie, J.G., Ho, C.T. Biofactors (2000) [Pubmed]
  24. Effects of Petroselinum crispum extract on pancreatic B cells and blood glucose of streptozotocin-induced diabetic rats. Yanardağ, R., Bolkent, S., Tabakoğlu-Oğuz, A., Ozsoy-Saçan, O. Biol. Pharm. Bull. (2003) [Pubmed]
  25. Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (uña de gato). Lemaire, I., Assinewe, V., Cano, P., Awang, D.V., Arnason, J.T. Journal of ethnopharmacology. (1999) [Pubmed]
  26. Piceatannol, a natural analog of resveratrol, inhibits progression through the S phase of the cell cycle in colorectal cancer cell lines. Wolter, F., Clausnitzer, A., Akoglu, B., Stein, J. J. Nutr. (2002) [Pubmed]
  27. Studies on the Taiwan folk medicine. VI. Studies on onitin. Yang, M.S. Planta Med. (1986) [Pubmed]
  28. Investigating the safety of plants used in South African traditional medicine: testing for genotoxicity in the micronucleus and alkaline comet assays. Taylor, J.L., Elgorashi, E.E., Maes, A., Van Gorp, U., De Kimpe, N., Van Staden, J., Verschaeve, L. Environ. Mol. Mutagen. (2003) [Pubmed]
  29. The analgesic activity of Hedyosmum bonplandianum: flavonoid glycosides. Cárdenas, L.C., Rodríguez, J., Villaverde, M.C., Riguera, R., Cadena, R., Otero, J.A. Planta Med. (1993) [Pubmed]
  30. Shark oil pneumonia. An overlooked entity. Asnis, D.S., Saltzman, H.P., Melchert, A. Chest (1993) [Pubmed]
  31. Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase[sol ]cyclooxygenase. Schneider, I., Bucar, F. Phytotherapy research : PTR. (2005) [Pubmed]
  32. Herbal interactions involving cytochrome p450 enzymes: a mini review. Delgoda, R., Westlake, A.C. Toxicological reviews. (2004) [Pubmed]
  33. Madimadi, Korean folk medicine, blocks TNF-alpha, IL-1beta, and IL-8 production by activated human immune cells. Kim, M.S., Yi, J.M., Kim, S.H., Hong, S.H., Kim, H.M. Cytokine (2004) [Pubmed]
  34. Inhibitory effect of ethyl acetate fraction from Cudrania tricuspidata on the expression of nitric oxide synthase gene in RAW 264.7 macrophages stimulated with interferon-gamma and lipopolysaccharide. Seo, W.G., Pae, H.O., Oh, G.S., Chai, K.Y., Yun, Y.G., Kwon, T.O., Chung, H.T. Gen. Pharmacol. (2000) [Pubmed]
  35. Home remedies to control head lice: assessment of home remedies to control the human head louse, Pediculus humanus capitis (Anoplura: Pediculidae). Takano-Lee, M., Edman, J.D., Mullens, B.A., Clark, J.M. Journal of pediatric nursing. (2004) [Pubmed]
  36. A review of nonvalidated and complementary therapies for cluster headache. Bilchik, T.R. Current pain and headache reports. (2004) [Pubmed]
  37. Pharmacokinetic interactions between Japanese traditional medicine (kampo) and modern medicine (III). Effect of Sho-seiryu-to on the pharmacokinetics of azelastine hydrochloride in rats. Makino, T., Inagaki, T., Komatsu, K., Kano, Y. Biol. Pharm. Bull. (2004) [Pubmed]
  38. A report on the composition of mercurials used in traditional medicines in Oman. Hardy, A.D., Sutherland, H.H., Vaishnav, R., Worthing, M.A. Journal of ethnopharmacology. (1995) [Pubmed]
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