The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Boswellia


High impact information on Boswellia

  • Commercially available extracts from Boswellia serrata resin used as anti-inflammatory drugs or phytonutrients show paradoxical concentration-dependent potentiating and inhibitory actions on 5-lipoxygenase (5-LO) product synthesis in stimulated PMNs [5].
  • Extracts from Boswellia serrata have been reported to have anti-inflammatory activity, primarily via boswellic acid-mediated inhibition of leukotriene synthesis [2].
  • 1. We have previously shown that 11-keto boswellic acids (11-keto-BAs), the active principles of Boswellia serrata gum resins, activate p38 MAPK and p42/44(MAPK) and stimulate Ca(2+) mobilisation in human polymorphonuclear leucocytes (PMNL) [6].
  • Although the boswellic acids could be identified as moderate to potent inhibitors of the applied CYP enzymes, they are not the major CYP inhibitory principle of frankincense [7].
  • LC/LC/ESI-MS fingerprint analyses of the boswellic acids 11-keto-beta-boswellic acid, alpha-boswellic acid, beta-boswellic acid and their 3-O-acylated derivatives were used for the authentication of the commercially obtained frankincense samples [7].

Biological context of Boswellia

  • Boswellic acid acetate (BC-4), a compound isolated from the herb Boswellia carterii Birdw., can induce differentiation and apoptosis of leukemia cells [8].
  • Mixed acetylboswellic acids, pentacyclic triterpenes extracted from the gum resin of Boswellia serrata Roxb., significantly inhibited the ionophore-stimulated release of the leukotrienes (LT) B4 and C4 from intact human polymorphonuclear neutrophil leukocytes (PMNLs), with IC50 values of 8.48 micrograms/ml and 8.43 micrograms/ml, respectively [9].
  • Pretreatment of aqueous extracts of Zyrulina (Spirulina), Aswagandha (Withania) and Nopane (Boswellia) on colchicine induced chromosome damage showed weakness of clastogenic activity in Swiss albino mice [10].

Anatomical context of Boswellia


Associations of Boswellia with chemical compounds

  • Out of 20 patients treated with Boswellia gum resin 14 went into remission while in case of sulfasalazine remission rate was 4 out of 10 [13].
  • The pentacyclic triterpenoid 3-acetyl-11-keto-beta-boswellic acid (AKBA) from the resin of Boswellia spec. is a potent inhibitor of 5-lipoxygenase (5-LO) [14].
  • The PDMS/DVB fiber was found to be the most efficient for trapping olibanum characteristic diterpenes, with a sampling time of 1 h and a sampling temperature of 80 degrees C [15].
  • The characteristic chemical compounds of Boswellia papyrifera are the diterpenic biomarkers incensole and its oxide and acetate derivatives, n-octanol and n-octyl acetate [16].
  • Oral therapy with the Boswellia extract or AKBA significantly reduces macroscopic and microcirculatory inflammatory features normally associated with indomethacin administration, indicating that the anti-inflammatory actions of the Boswellia extract in IBD may be due in part to boswellic acids such as AKBA [17].

Gene context of Boswellia

  • Here we show that extracts of Boswellia serrata gum resins and its constituents, the boswellic acids (BAs), activate the mitogen-activated protein kinases (MAPK) p42(MAPK) and p38 in isolated human polymorphonuclear leukocytes (PMNL) [18].
  • The stems of Boswellia ovalifoliolata BAL. & HENRY (Burseraceae) afforded two new macrocyclic diaryl ether heptanoids, ovalifoliolatin A (1) and B (2) together with three known compounds; acerogenin C (3), 3 alpha-hydroxyurs-12-ene (4), and sitost-4-en-3-one (5) [19].


  1. Determination of boswellic acids in brain and plasma by high-performance liquid chromatography/tandem mass spectrometry. Reising, K., Meins, J., Bastian, B., Eckert, G., Mueller, W.E., Schubert-Zsilavecz, M., Abdel-Tawab, M. Anal. Chem. (2005) [Pubmed]
  2. Effects of Boswellia serrata in mouse models of chemically induced colitis. Kiela, P.R., Midura, A.J., Kuscuoglu, N., Jolad, S.D., Sólyom, A.M., Besselsen, D.G., Timmermann, B.N., Ghishan, F.K. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  3. Interventions for treating collagenous colitis. Chande, N., McDonald, J.W., Macdonald, J.K. Cochrane database of systematic reviews (Online) (2005) [Pubmed]
  4. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study. Kulkarni, R.R., Patki, P.S., Jog, V.P., Gandage, S.G., Patwardhan, B. Journal of ethnopharmacology. (1991) [Pubmed]
  5. Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid. Boden, S.E., Schweizer, S., Bertsche, T., Düfer, M., Drews, G., Safayhi, H. Mol. Pharmacol. (2001) [Pubmed]
  6. Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Altmann, A., Poeckel, D., Fischer, L., Schubert-Zsilavecz, M., Steinhilber, D., Werz, O. Br. J. Pharmacol. (2004) [Pubmed]
  7. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. Frank, A., Unger, M. Journal of chromatography. A. (2006) [Pubmed]
  8. Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines. Jing, Y., Nakajo, S., Xia, L., Nakaya, K., Fang, Q., Waxman, S., Han, R. Leuk. Res. (1999) [Pubmed]
  9. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Wildfeuer, A., Neu, I.S., Safayhi, H., Metzger, G., Wehrmann, M., Vogel, U., Ammon, H.P. Arzneimittel-Forschung. (1998) [Pubmed]
  10. Clastogenic effects of dietary supplement--Spirulina alga, and some medicinal plant products from Boswellia serrata, Withania somnifera on mice. Ghoshal, S., Mukhopadhyay, M.J., Mukherjee, A. Indian J. Exp. Biol. (2001) [Pubmed]
  11. Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata. Ammon, H.P., Mack, T., Singh, G.B., Safayhi, H. Planta Med. (1991) [Pubmed]
  12. Extract of gum resins of Boswellia serrata L. inhibits lipopolysaccharide induced nitric oxide production in rat macrophages along with hypolipidemic property. Pandey, R.S., Singh, B.K., Tripathi, Y.B. Indian J. Exp. Biol. (2005) [Pubmed]
  13. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Gupta, I., Parihar, A., Malhotra, P., Gupta, S., Lüdtke, R., Safayhi, H., Ammon, H.P. Planta Med. (2001) [Pubmed]
  14. 3-Acetoxy group of genuine AKBA (acetyl-11-keto-beta-boswellic acid) is alpha-configurated. Schweizer, S., Eichele, K., Ammon, H.P., Safayhi, H. Planta Med. (2000) [Pubmed]
  15. Optimization of headspace solid phase microextraction for gas chromatography/mass spectrometry analysis of widely different volatility and polarity terpenoids in olibanum. Hamm, S., Lesellier, E., Bleton, J., Tchapla, A. Journal of chromatography. A. (2003) [Pubmed]
  16. A chemical investigation by headspace SPME and GC-MS of volatile and semi-volatile terpenes in various olibanum samples. Hamm, S., Bleton, J., Connan, J., Tchapla, A. Phytochemistry (2005) [Pubmed]
  17. Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis. Krieglstein, C.F., Anthoni, C., Rijcken, E.J., Laukötter, M., Spiegel, H.U., Boden, S.E., Schweizer, S., Safayhi, H., Senninger, N., Schürmann, G. International journal of colorectal disease. (2001) [Pubmed]
  18. Boswellic acids activate p42(MAPK) and p38 MAPK and stimulate Ca(2+) mobilization. Altmann, A., Fischer, L., Schubert-Zsilavecz, M., Steinhilber, D., Werz, O. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  19. Two new macrocyclic diaryl ether heptanoids from Boswellia ovalifoliolata. Lakshmi Niranjan Reddy, V., Ravinder, K., Srinivasulu, M., Venkateshwar Goud, T., Malla Reddy, S., Srujankumar, D., Prabhakar Rao, T., Suryanarayana Murty, U., Venkateswarlu, Y. Chem. Pharm. Bull. (2003) [Pubmed]
WikiGenes - Universities