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Chemical Compound Review:

AC1NSXT0 (2S,3R,5R,10R,13R,17S)- 2,3,14-trihydroxy...

Synonyms:

Kaplanis, J.N. et al., Kaufman, W.R., Feldlaufer, M.F. et al., Gilgan, M.W., Lundström, A. et al.

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High impact information on Makisterone A

Makisterone A is the predominant ecdysone in the 96 +/- 4-hour-old embryo of the large milkweed bug and it is the first molting hormone with a C-24 alkyl substituent of the side chain to be isolated and identified from an insect [1].
Separation of ecdysterone, inokosterone, makisterone A, alpha-ecdysone and ponasterone A by a combination of adsorptive and reversed-phase liquid chromatography [2].
The purified protein mediates the reduction of 3-dehydromakisterone A to makisterone A, and requires NADPH as a cofactor [3].
Ecdysone and 20-hydroxyecdysone were the predominant ecdysteroids in insects from all diet studies, though makisterone A was detected in pupae reared on campesterol and sitosterol [4].
Two phytecdysteroids (abutasterone, makisterone A) and five synthetic ecdysteroid analogues, all at 1 microgram/ml, were tested on salivary glands from the female tick, Amblyomma americanum L [5].

References

Makisterone A:a 28-carbon hexahydroxy molting hormone from the embryo of the milkweed bug. Kaplanis, J.N., Dutky, S.R., Robbins, W.E., Thompson, M.J., Lindquist, E.L., Horn, D.H., Galbraith, M.N. Science (1975) [Pubmed]
Separation of ecdysterone, inokosterone, makisterone A, alpha-ecdysone and ponasterone A by a combination of adsorptive and reversed-phase liquid chromatography. Gilgan, M.W. J. Chromatogr. (1976) [Pubmed]
A protein from the cabbage looper, Trichoplusia ni, regulated by a bacterial infection is homologous to 3-dehydroecdysone 3beta-reductase. Lundström, A., Kang, D., Liu, G., Fernandez, C., Warren, J.T., Gilbert, L.I., Steiner, H. Insect Biochem. Mol. Biol. (2002) [Pubmed]
Ecdysteroid production in Drosophila melanogaster reared on defined diets. Feldlaufer, M.F., Weirich, G.F., Imberski, R.B., Svoboda, J.A. Insect Biochem. Mol. Biol. (1995) [Pubmed]
Further investigations on the action of ecdysteroids on the salivary glands of the female tick Amblyomma americanum. Kaufman, W.R. Exp. Appl. Acarol. (1991) [Pubmed]

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